Hydrochlorothiazide

CAS Number 58-93-5
Molecular Formula C7H8ClN3O4S2
Molecular Weight 297.731 g/mol
InChI Key JZUFKLXOESDKRF-UHFFFAOYSA-N
LogP -0.0700
Synonyms
  • Hydrochlorothiazide
  • 6-Chloro-1,1-dioxo-1,2,3,4-tetrahydro-1lambda6,2,4-benzothiadiazine-7-sulfonamide
  • 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-, 1,1-dioxide
  • 58-93-5
  • 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-, 1,1-dioxide
  • 3,4-Dihydrochlorothiazide
  • 6-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
  • 6-Chloro-3,4-dihydro-7-sulfamoyl-2H-1,2,4-benzothiadiazine 1,1-dioxide
  • 6-Chloro-7-sulfamoyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide
  • 6-Chloro-7-sulfamoyl-3,4-dihydrobenzo-1,2,4-thiadiazine-1,1-dioxide
  • Acuretic
  • Apo-Hydro
  • Apresazide
  • Aquarius
  • Aquazide
  • Aquazide H
  • Caplaril
  • Carozide
  • Chlorosulthiadil
  • Chlorsulthiadil
  • Clorana
  • Clothia
  • Dichlothiazide
  • Dichlotiazid
  • Dichlotride
  • Dichlozid
  • Diclotride
  • Didralin
  • Dihydrochlorothiazide
  • Dihydrochlorothiazidum
  • Dihydrochlorurit
  • Dihydrochlorurite
  • Disalunil
  • Disothiazide
  • Diuret-P
  • Diurizid
  • Esidrex
  • Esidrix
  • Hidrenox
  • Hidrochlortiazid
  • hidroclorotiazida
  • Hidrosaluretil
  • Hidrotiazida
  • Hydrex-semi
  • Hydro Par
  • Hydro-Aquil
  • Hydrochlorothiazid
  • Hydrochlorthiazide
  • Hydrochlorzide
  • Hydrocot
  • Hydrodiuretic
  • Hydro-Diuril
  • Hydrosaluric
  • Hydro-T
  • Hydrozide
  • Hypothiazid
  • Hypothiazide
  • Idrodiuvis
  • Idrotiazide
  • Lopressor HCT
  • Lotensin HCT
  • Manschitt
  • Maschitt
  • Megadiuril
  • Microzide
  • Natrimax
  • Neoflumen
  • Newtolide
  • NSC 53477
  • Pantemon
  • Servithiazid
  • Tandiur
  • Thiuretic
  • Timolide
  • Unipres
  • Vaseretic
  • Vetidrex
  • Aldactazide 25/25
  • Aldectazide 50/50
  • Aquazide-H
  • 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-, 1, 1-dioxide
  • BRN 0625101
  • Chlorizide
  • 3,4-Dihydro-6-chloro-7-sulfamyl-1,2,4-benzothiadiazine-1,1-dioxide
  • Diu-melusin
  • EINECS 200-403-3
  • Hydrochlorthiazidum
  • Inderide 80/25
  • Mazide 25 mg
  • Mictrin
  • NCI-C55925
  • Spironazide
  • Neo-Flumen
  • Acesistem
  • Acuilix
  • Aldazida
  • Briazide
  • Catiazida
  • Chlothia
  • Condiuren
  • Dihydran
  • Disothiazid
  • Diu 25 Vigt
  • Diurogen
  • Dixidrasi
  • Esoidrina
  • HCT-Isis
  • Hidro-Niagrin
  • Hyclosid
  • Hydrochlorothiazidum
  • Hydro-Saluric
  • Indroclor
  • Manuril
  • Medozide
  • Mikorten
  • Modurcen
  • Natrinax
  • Neo-Minzil
  • Novodiurex
  • Raunova Plus
  • Saldiuril
  • Selozide
  • Urozide
  • Concor Plus
  • Hydrochlorot
  • Hydrochlorat
  • Idroclorotiazide
  • UNII-0J48LPH2TH
  • 6-chloro-1,1-dioxo-3,4-dihydro-2H-1l6,2,4-benzothiadiazine-7-sulfonamide
  • Aldactazide
  • Aldoril
  • Aquarills
  • Bremil
  • Capozide
  • Chlorosulthiadil
  • Chlorothiazide
  • Chlorsulfonamidodihydrobenzothiadiazine dioxide
  • Chlorzide
  • Cidrex
  • Dichlorosal
  • Dihydrochlorothiazid
  • Dihydrochlorothiazidum
  • Dihydroxychlorothiazidum
  • Direma
  • Diuril
  • Drenol
  • Dyazide
  • Esidrix (TN)
  • Esimil
  • Fluvin
  • HCTZ
  • HCZ
  • Hidril
  • Hidrochlortiazid
  • Hidroronol
  • Hydril
  • Hydro-D
  • Hydrochloro Thiazide
  • Hydrochlorothiazide Intensol
  • Hydrodiuril
  • Hydropres
  • Hydrothide
  • Hyzaar
  • Inderide
  • Ivaugan
  • Jen-Diril
  • Maxzide
  • Moduretic
  • Nefrix
  • Neo-codema
  • Oretic
  • Panurin
  • Prinzide
  • Ro-hydrazide
  • Ser-Ap-Es
  • Thiaretic
  • Thlaretic
  • Urodiazin
  • Ziac
  • Zide
  • 125727-50-6
  • 8049-49-8

Applications:


HPLC Method for Analysis of Hydrochlorothiazide
Chr_1047

Hydrochlorothiazide is a thiazide diuretic often considered the prototypical member of the class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of high blood pressure and swelling due to fluid build-up as well as several disorders such as edema, hypertension, diabetes insipidus, and hypoparathyroidism. Primesep 200, a reverse phase column, contains embedded acidic ionizable groups and can retain Hydrochlorothiazide. The method is UV compatible and can be used as a general approach for analyzing similar compounds.

Condition

Column Primesep 200, 3.2x100 mm, 5 µm, 100A
Mobile Phase Gradient MeCN - 5-50%
Buffer Gradient H3PO4 - 0.05-0.3%, 5 min, 4 min hold
Flow Rate 0.5 ml/min
Detection UV, 270 nm
   

Description

Class of Compounds Drug,  Acid, Hydrophilic, Ionizable,
Analyzing Compounds Hydrochlorothiazide


Application Analytes:

Hydrochlorothiazide