Hydroxyzine dihydrochloride

Hydroxyzine dihydrochloride structural formula
UV Spectra of Hydroxyzine

UV Spectra of Hydroxyzine

CAS Number2192-20-3
Molecular FormulaC21H29Cl3N2O2
Molecular Weight447.830
InChI KeyANOMHKZSQFYSBR-UHFFFAOYSA-N
LogP2.35
Synonyms
  • Hydroxyzine dihydrochloride
  • 2-(2-{4-[(4-Chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)ethan-1-ol--hydrogen chloride (1/2)
  • Ethanol, 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-, hydrochloride (1:2)
  • 2192-20-3
  • Ataraxoid dihydrochloride
  • 2-(2-(4-(p-Chloro-alpha-phenylbenzyl)-1-piperazinyl)ethoxy)ethanol dihydrochloride
  • EINECS 218-586-3
  • Neurolax
  • Orgatrax
  • Tran-Q dihydrochloride
  • Tranquizine dihydrochloride
  • Vistaril steraject
  • Arcanax
  • Vistazine
  • Vistaject
  • Vistarex
  • Atranine A
  • Dichlorhydrate de 1-p.chlorbenzhydryl-4-(2-(2-hydroxyethoxy)ethyl)piperazine
  • UNII-76755771U3
  • Atarax dihydrochloride
  • Hydroxyzine HCl
  • hydroxyzine hydrochloride

Applications:

HPLC Method for Determination of Hydroxyzine in Tablets on Primesep SB Column

November 27, 2018
HPLC Determination of Hydroxyzine in Tablets_1152
HPLC Method for Analysis of Hydroxyzine, Hydroxyzine dihydrochloride on Primesep SB Column by SIELC Technologies

Hydroxyzine is an antihistamine medication that is used to treat various conditions.

Antihistamine: Hydroxyzine belongs to the class of drugs known as first-generation antihistamines. It works by blocking the effects of histamine, a natural substance in the body that is involved in allergic reactions.

Uses: Hydroxyzine is used to treat itching caused by allergies, as well as to relieve symptoms of allergic reactions such as hives. It is also used as a sedative to manage anxiety and tension.

Allergic Reactions: In the context of allergic reactions, hydroxyzine helps alleviate symptoms like itching, redness, and swelling by blocking histamine receptors.

Anxiolytic Properties: It has sedative and anxiolytic (anxiety-reducing) properties, and it is sometimes prescribed to manage anxiety and tension.

Forms: Hydroxyzine is available in various forms, including tablets, capsules, and oral solutions. It can also be administered by injection in certain medical situations.

Precautions: It’s important to use hydroxyzine with caution, especially in situations that require alertness, as it can cause drowsiness. It should be avoided or used with caution in individuals with certain medical conditions.

Prescription Required: Hydroxyzine is typically available by prescription, and the dosage should be determined by a healthcare professional based on the specific condition being treated.

Hydroxyzine be retained and analyzed using a Primesep SB mixed-mode stationary phase column. The analysis employs an isocratic method with a simple mobile phase comprising water, acetonitrile (MeCN), and sulfuric acid as a buffer. This method allows for detection using UV at 232 nm

ColumnPrimesep SB, 4.6 x 150 mm, 5 µm, 100 A
Mobile PhaseMeCN/H2O – 20/80%
BufferH2SO4 – 0.1%
Flow Rate1.0 ml/min
DetectionUV, 232 nm
Class of Compounds
Drug, Antihistamine, Base, Hydrophobic, Ionizable
Analyzing CompoundsHydroxyzine

Application Column

Primesep SB

Column Diameter: 4.6 mm
Column Length: 150 mm
Particle Size: 5 µm
Pore Size: 100 A

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Application Analytes:
Hydroxyzine
Hydroxyzine dihydrochloride
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

Separation of Hydroxyzine dihydrochloride on Newcrom R1 HPLC column

February 16, 2018
Separation of Hydroxyzine dihydrochloride on Newcrom C18 HPLC column

Hydroxyzine dihydrochloride can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
Hydroxyzine dihydrochloride
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: support@sielc.com or by phone: 847-229-2629.