Inosine

Inosine structural formula

CAS Number 58-63-9
Molecular Formula C10H12N4O5
Molecular Weight 268.230 g/mol
InChI Key UGQMRVRMYYASKQ-KQYNXXCUSA-N
LogP -2.10
Synonyms
  • Inosine
  • 9-beta-D-Ribofuranosyl-9H-purin-6-ol
  • 9H-Purin-6-ol, 9-beta-D-ribofuranosyl-
  • 58-63-9
  • 1,9-Dihydro-9-β-D-ribofuranosyl-6H-purin-6-one
  • 6H-Purin-6-one, 1,9-dihydro-9-β-D-ribofuranosyl-
  • 9-β-D-Ribofuranosylhypoxanthine
  • Hypoxanthine 9-β-D-ribofuranoside
  • Hypoxanthine ribonucleoside
  • Hypoxanthine riboside
  • Hypoxanthine, 9-β-D-ribofuranosyl-
  • Hypoxanthosine
  • inosina
  • NSC 20262
  • Oxiamin
  • Panholic-L
  • Ribonosine
  • Trophicardyl
  • EINECS 200-390-4
  • Hypoxanthine, 9-beta-D-ribofuranosyl-
  • beta-D-Ribofuranoside, hypoxanthine-9
  • Inosinum
  • UNII-5A614L51CT
  • (-)-Inosine
  • 1,9-Dihydro-9-b-D-ribofuranosyl-6H-Purin-6-one
  • 1,9-Dihydro-9-beta-D-ribofuranosyl-6H-purin-6-one
  • 1,9-Dihydro-9-beta-delta-ribofuranosyl-6H-purin-6-one
  • 9-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one
  • 9-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-3H-purin-6-one
  • 9-[(2R,3R,4R,5R)-3,4-dihydroxy-5-methylol-tetrahydrofuran-2-yl]-3H-purin-6-one
  • 9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6,9-dihydro-1H-purin-6-one
  • 9-b-D-Ribofuranosyl-Hypoxanthine
  • 9-b-D-Ribofuranosylhypoxanthine
  • 9-beta-D-Ribofuranosyl-Hypoxanthine
  • 9-beta-D-ribofuranosyl-9H-purin-6-ol
  • 9-beta-D-ribofuranosylhypoxanthine
  • 9-beta-delta-Ribofuranosyl-Hypoxanthine
  • 9-beta-delta-Ribofuranosylhypoxanthine
  • 9beta-D-Ribofuranosylhypoxanthine
  • 9beta-delta-Ribofuranosylhypoxanthine
  • Atorel
  • HXR
  • Hypoxanthine 9-beta-D-ribofuranoside
  • Hypoxanthine 9-beta-delta-ribofuranoside
  • Hypoxanthine nucleoside
  • Hypoxanthine-9 beta-D-Ribofuranoside
  • Hypoxanthine-9 beta-delta-Ribofuranoside
  • Hypoxanthine-9-D-ribofuranoside
  • Hypoxanthine-9-beta-D-ribofuranoside
  • Hypoxanthine-9-beta-delta-ribofuranoside
  • Hypoxanthine-9-delta-ribofuranoside
  • Hypoxanthine-ribose
  • Indole-3-carboxaldehyde
  • Ino
  • Inosie
  • Inosin
  • Iso-prinosine
  • Pantholic-L
  • Selfer
  • beta-D-Ribofuranoside hypoxanthine-9
  • beta-Inosine
  • beta-delta-Ribofuranoside hypoxanthine-9
  • hypoxanthine D-riboside
  • i
  • 12712-98-0
  • 132953-54-9
  • 28861-88-3
  • 292853-81-7
  • 4181-51-5
  • 691344-25-9
  • 740029-83-8

Applications:


HPLC Separation of Inosine and Deoxyinosine

Condition

Column Sharc 1, 3.2x100 mm, 5 µm, 100A
Mobile Phase MeCN/MeOH - 97/3%
Buffer Formic Acid 0.1% , AmFm - 0.01%
Flow Rate 1.0 ml/min
Detection UV, 270 nm
 

Description

Class of Compounds Nucleoside monophosphate, Hydrophilic, Ionizable
Analyzing Compounds Inosine, Deoxyinosine
 

Application Analytes:

2-Deoxyinosine
Inosine

HPLC Analysis of Inosine
     

Inosine is a nucleoside made of a hypoxanthine and a ribose ring. As a drug, Inosine is useful for the treatment of various autoimmune diseases. Legacy L1 was used to retain Inosine by reverse phase mechanism. Legacy L1 uses embedded C18 groups on porous silica and is useful for many USP HPLC applications. comparisons to Phenomenex columns are available by request.

Condition

Column Legacy L1, 4.6x250 mm, 5 µm, 100A
Mobile Phase MeOH - 10%
Buffer No
Flow Rate 1.0 ml/min
Detection UV, 248 nm
 

Description

Class of Compounds  Nucleoside,  Hydrophilic, Ionizable
Analyzing Compounds Inosine
 


Application Analytes:

Inosine

HPLC Separation of Acedoben and Inosine on SHARC 1 Column
HPLC.cloud View on hplc.cloud Inosine pranobex is an antiviral drug. A combination of inosine and dimepranol acedoben (a salt of acetamidobenzoic acid and dimethylaminoisopropanol) has no effect on viral particles itself. Instead, it acts as an immunostimulant. It is most commonly used to treat the rare measles complication subacute sclerosing panencephalitis in conjunction with intrathecal interferon therapy. Chromatography of these two compounds can be difficult due to their high polarity. But both compounds can be well retained and separated using anhydrous (water-free) conditions using HPLC on SHARC 1 column, which uses hydrogen-bonding as a separation mechanism. The method uses a gradient of acetonitrile (ACN) and methanol (MeOH) mobile phase with volatile buffer containing Formic Acid 0.1% and AmFm - 0.01%, making the method MS-compatible. Both compounds can also be UV detected at 270 nm.  

Condition

Column Sharc 1, 4.6x150 mm, 5 µm, 100A
Mobile Phase MeCN/MeOH
Buffer Formic Acid 0.1% , AmFm - 0.01%
Flow Rate 1.0 ml/min
Detection UV 270 nm
 

Description

Class of Compounds Nucleoside monophosphate, Hydrophilic, Ionizable
Analyzing Compounds Inosine, Acedoben
 

Application Analytes:

4-Aminobenzoic Acid
Inosine