Iodide

CAS Number	20461-54-5
Molecular Formula	I-
Molecular Weight	126.9045 g/mol
InChI Key	XMBWDFGMSWQBCA-UHFFFAOYSA-M
LogP	2.9
Synonyms	Iodide Iodide ion trihydridoiodine 20461-54-5 Iodide(1-) Iodide-127 iodinane iodine anion Iodide anion Iodide Salt lambda(3)-iodane UNII-09G4I6V86Q I- 09G4I6V86Q Colloidal iodine Iodine ion Iodide ion(1-) Iodine(1-) Iodine, ion (I1-) hydriodic acid, ion(1-) CHEMBL185537 BDBM26981 CHEBI:16382 CHEBI:37181 CTK1A4386 DTXSID80912339 [IH5] Iodide (6CI,7CI,8CI,9CI) Ba 2796 DB12754 C00708 Q407654 Q27117062

Applications:

HPLC Method for Analysis of Iodide and Thyroid Hormones

Iodine is an important element in production of thyroid hormones, T3 and T4, which are essential regulators of organism's metabolism. The glands' concentration of Iodide, hormones T3 and T4, along with their precursors: 3,5-Diiodo-L-thyronine (T2), 3,5-Diiodo-L-tyrosine (DIT), and 3-Iodo-L-tyrosine (MIT) can now be studied simultaneously with this HPLC method. In order to analyze the hydrophobic hormones along with iodide (a very polar inorganic ion) a special mixed-mode column, Primesep D, was used. This column provides both strong hydrophobic and anion exchange properties. The Primesep D silica-bonded ligand is comprised of a long alkyl chain and an embedded amino functional group. The TFA was used as an ionic modifier to provide stable acidic pH and sufficient ion strength for the mobile phase. The mobile phase composition is suitable for UV, MS, ELSD, and CAD detection.

Condition
Column	Primesep D, 4.6x150 mm, 5 µm, 100A
Mobile Phase	MeCN
Buffer	TFA
Flow Rate	1.0 ml/min
Detection	UV, 230 nm

Description
Class of Compounds	Drug, Hydrophilic, Ionizable, Supplements
Analyzing Compounds	T3, T4, 3,5-Diiodo-L-thyronine (T2), 3,5-Diiodo-L-tyrosine (DIT), and 3-Iodo-L-tyrosine (MIT)

3,5-Diiodo-L-thyronine (T2)
3,5-Diiodo-L-tyrosine dihydrate (DIT)
3-Iodo-L-tyrosine (MIT)
Iodide
Iodine
Levothyroxine (T4)
Liothyronine (T3)
Methimazole

HPLC Separation of Inorganic Anions on Newcrom BH Column

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Condition
Column	Newcrom BH, 4.6x150 mm, 5 µm, 100A
Mobile Phase	MeCN/H2O - 10/90%
Buffer	Gradient AmAc pH 5.0 - 20-90 mM , 20 min
Flow Rate	1.0 ml/min
Detection	CAD (Corona) (MS-compatible mobile phase)