L-Methionine

CAS Number 63-68-3
Molecular Formula C5H11NO2S
Molecular Weight 149.211 g/mol
InChI Key FFEARJCKVFRZRR-BYPYZUCNSA-N
LogP -1.87
Synonyms
  • L-Methionine
  • 63-68-3
  • (S)-2-Amino-4-(methylthio)butanoic acid
  • 2-Amino-4-(methylthio)butyric acid
  • 2-Amino-4-methylthiobutanoic acid
  • Acimethin
  • Butanoic acid, 2-amino-4-(methylthio)-, (S)-
  • Cymethion
  • h-Met-oh
  • L-(-)-Methionine
  • L-Homocysteine, S-methyl-
  • L-Methionin
  • L-metionina
  • L-?-Amino-?-methylthiobutyric acid
  • METHIONINE, L-
  • NSC 22946
  • Protein (human clone US2003/0049618-SEQID-395 secreted protein sequence homolog)
  • Secretory peptide (human clone HTXDU73)
  • S-Methionine
  • S-Methyl-L-homocysteine
  • Soft tissue sarcoma-associated protein (human clone WO2004048938-SEQID-1139)
  • ?-Methylthio-?-aminobutyric acid
  • 2-Amino-4-methylthiobutanoic acid (S)-
  • 2-Amino-4-(methylthio)butyric acid, (S)-
  • EINECS 200-562-9
  • Methioninum
  • UNII-AE28F7PNPL
  • (2S)-2-amino-4-(methylsulfanyl)butanoate
  • (2S)-2-amino-4-(methylsulfanyl)butanoic acid
  • (2S)-2-amino-4-methylsulfanyl-butanoic acid
  • (L)-methionine
  • (S)-(+)-methionine
  • (S)-2-Amino-4-(methylthio)butanoate
  • (S)-2-amino-4-(methylthio)-Butanoate
  • (S)-2-amino-4-(methylthio)-Butanoic acid
  • (S)-2-amino-4-(methylthio)butyric acid
  • (S)-methionine
  • 2-Amino-4-(methylthio)butyrate
  • 2-Amino-4-methylthiobutanoate
  • A-Amino-g-methylmercaptobutyrate
  • A-Amino-g-methylmercaptobutyric acid
  • G-Methylthio-a-aminobutyrate
  • G-Methylthio-a-aminobutyric acid
  • H-Met-h
  • L(-)-Amino-alpha-amino-alpha-aminobutyric acid
  • L(-)-Amino-gamma-methylthiobutyric acid
  • L-2-Amino-4-(methylthio)butyric acid
  • L-2-Amino-4-methylthiobutyric acid
  • L-Methioninum
  • L-a-Amino-g-methylthiobutyrate
  • L-a-Amino-g-methylthiobutyric acid
  • L-alpha-Amino-gamma-methylthiobutyrate
  • L-alpha-Amino-gamma-methylthiobutyric acid
  • L-alpha-amino-gamma-methylmercaptobutyric acid
  • L-gamma-Methylthio-alpha-aminobutyric acid
  • Liquimeth
  • Mepron
  • Methilanin
  • Methionine
  • Methioninum
  • Metionina
  • Neo-methidin
  • Poly-L-methionine
  • Polymethionine
  • Toxin WAR
  • alpha-Amino-alpha-aminobutyric acid
  • alpha-Amino-gamma-methylmercaptobutyrate
  • alpha-Amino-gamma-methylmercaptobutyric acid
  • gamma-Methylthio-alpha-aminobutyrate
  • gamma-Methylthio-alpha-aminobutyric acid
  • (2S)-2-ammonio-4-(methylsulfanyl)butanoate
  • L-methionine zwitterion
  • 24425-78-3
  • 7005-18-7

Applications:


Separation of L-Methionine on Newcrom R1 HPLC column

L-Methionine can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Separation of L-Methionine on Newcrom C18 HPLC column
Newcrom R1

This column is available in new type of hardware with only one connection end. Learn more about performance and advantage of this new hardware.



Application Analytes:

L-Methionine

HPLC Separation of Mixture of Essential Amino Acids on Primesep 100 Column
 

Condition

Column Primesep 100, 4.6x250 mm, 5 µm, 100A
Mobile Phase MeCN/H2O - 20/80%
Buffer Gradient H2SO4 0.05-0.2% 25 min
Flow Rate 1.0 ml/min
Detection UV, 200 nm
 

Description

Class of Compounds Drug, Acid, Hydrophilic, Ionizable, Vitamin, Supplements, Amino acid
Analyzing Compounds Amino acids
 

Application Analytes:

Amino Acids
D-Isoleucine
D-Leucine
D-Valine
DL-Isoleucine
Histidine
Isoleucine
L-Histidine hydrochloride monohydrate
L-Isoleucine
L-Methionine
Methionine
Phenylalanine
Tryptophan
Valine

HPLC Separation of Mixture of 12 Amino Acids on Primesep 100 Column
 

Condition

Column Primesep 100, 4.6x250 mm, 5 µm, 100A
Mobile Phase MeCN/H2O - 35/65%
Buffer H2SO4 0.05% 12 min hold, gradient 0.05-0.20, 13 min
Flow Rate 1.0 ml/min
Detection UV, 200 nm
 

Description

Class of Compounds Drug, Acid, Hydrophilic, Ionizable, Vitamin, Supplements, Amino acid
Analyzing Compounds Amino acids
 

Application Analytes:

Amino Acids
Arginine
Asparagine
Cysteine
D-Isoleucine
D-Leucine
D-Valine
DL-Isoleucine
Histidine
Isoleucine
L-Cysteine
L-Methionine
Leucine
Methionine
Phenylalanine
Proline
Tryptophan
Valine