Lisinopril dihydrate

Lisinopril dihydrate structural formula

CAS Number 83915-83-7
Molecular Formula C21H35N3O7
Molecular Weight 441.525 g/mol
InChI Key CZRQXSDBMCMPNJ-ZUIPZQNBSA-N
LogP -0.0887
Synonyms
  • Lisinopril dihydrate
  • N2-[(1S)-1-Carboxy-3-phenylpropyl]-L-lysyl-L-proline--water (1/2)
  • L-Proline, N2-[(1S)-1-carboxy-3-phenylpropyl]-L-lysyl-, hydrate (1:2)
  • 83915-83-7
  • L-Proline, N2-[(1S)-1-carboxy-3-phenylpropyl]-L-lysyl-, dihydrate
  • (S)-1-(N2-(1-Carboxy-3-phenylpropyl)-L-lysyl)-L-proline dihydrate
  • (S)-1-(N(sup 2)-(1-Carboxy-3-phenylpropyl)-L-lysyl)-L-proline dihydrate
  • UNII-E7199S1YWR
  • Ranolip
  • (S)-1-(N(2)-(1-carboxy-3-phenylpropyl)-L-lysyl)-L-proline dihydrate
  • Lisinopril
  • Renacor

Applications:

Separation of Lisinopril dihydrate on Newcrom R1 HPLC column

Lisinopril dihydrate can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Separation of Lisinopril dihydrate on Newcrom C18 HPLC column
Newcrom R1

This column is available in new type of hardware with only one connection end. Learn more about performance and advantage of this new hardware.

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Application Analytes:

Lisinopril dihydrate
HPLC Separation of Enalapril and Lisinopril on Newcrom AH Column
Separation type: Liquid Chromatography Mixed-mode

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High Performance Liquid Chromatography (HPLC) Method for Analysis of Enalapril and Lisinopril
Enalapril and lisinopril are medications that work on the kidneys to help lower blood pressure. Lisinopril can be used for heart failure and for people who’ve had a heart attack. Enalapril can also be used for heart failure but not heart attacks. By using a Newcrom AH mixed-mode column with a cation-exchange mechanism, enalapril and lisinopril, can be baseline separated in a short time using an isocratic method with a simple mobile phase of water, acetonitrile (MeCN, ACN) and a sulfuric acid (H2SO4) buffer. UV detection at 210 nm.


Condition
Column Newcrom AH, 4.6x150 mm, 5 µm, 100A
Mobile Phase MeCN/H2O - 50/50%
Buffer  H2SO4 - 0.5%
Flow Rate 1.0 ml/min
Detection UV, 210 nm
 

Description
Class of Compounds Drug
Analyzing Compounds Enalapril,  Lisinopril, Maleic Acid
 
Application Analytes:

Enalapril
Lisinopril
Lisinopril dihydrate