| CAS Number | 5026-62-0 |
|---|---|
| Molecular Formula | C8H7NaO3 |
| Molecular Weight | 174.131 g/mol |
| InChI Key | PESXGULMKCKJCC-UHFFFAOYSA-M |
| LogP | 1.24 |
| Synonyms |
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Applications:
Separation of Methylparaben sodium on Newcrom R1 HPLC column
Methylparaben sodium can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.
Newcrom R1
This column is available in new type of hardware with only one connection end. Learn more about performance and advantage of this new hardware.
Application Analytes:
Methylparaben sodium
HPLC Separation of Mixture of Carbocisteine, Methylparaben & Propylparaben on Primesep 100 Column
Carbocysteine is a medication that reduces the viscosity of mucus making it easier to cough up. Methylparaben and propylparaben are used as preservatives in cosmetics, pharmaceuticals and food. They can be separated in HPLC on a Primesep 100 mixed-mode column by both hydrophobic and ionic properties present on the stationary phase. The analytical method uses acetonitrile (ACN) gradient and water with sulfuric acid (H2SO4) as buffer and UV detected at 200nm.
| Column | Primesep 100, 4.6x150 mm, 5 µm, 100A |
| Mobile Phase | Gradient MeCN - 2-50%, 20 min |
| Buffer | H2SO4 - 0.05 % |
| Flow Rate | 1.0 ml/min |
| Detection | UV, 200 nm |
| Class of Compounds | Drug, Acid, Hydrophilic, Ionizable, Carboxylic acid, Carbocyclic, Benzoate, Hydroxy Acid, Amino Acid, Hydroxybenzoate, Phenol |
| Analyzing Compounds | Carbocisteine, Methylparaben, Propylparaben |
Application Analytes:
Carbocisteine
Methylparaben
Methylparaben sodium
Propylparaben
Propylparaben sodium
HPLC Determination of EDTA, Phenoxyethanol and Methylparaben in Facial Cleanser on Newcrom BH
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| Column | Newcrom BH, 4.6x150 mm, 100A |
| Mobile Phase | Gradient MeCN - 2- 70%, 10 min |
| Buffer | H2SO4 - 0.1% |
| Flow Rate | 1.0 ml/min |
| Detection | UV 260nm |
| Class of Compounds | Acid, Hydrophilic, Preservatives |
| Analyzing Compounds | EDTA, Methylparaben, Phenoxyethanol |
Application Analytes:
2-Phenoxyethanol
EDTA (Ethylenediaminetetraacetic Acid)
Methylparaben
Methylparaben sodium
HPLC Analysis of Paraben Preservatives on Newcrom AH Column
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| Column | Newcrom AH, 3.2x100 mm, 5 µm, 100A |
| Mobile Phase | MeCN/H2O - 30/70% |
| Buffer | H2SO4 - 0.1% |
| Flow Rate | 0.5 ml/min |
| Detection | UV, 270 nm |
| Class of Compounds | Preservatives, Hydrophobic |
| Analyzing Compounds | Methyl Paraben, Ethyl Paraben, Propyl Paraben |
Application Analytes:
Ethylparaben
Methylparaben
Methylparaben sodium
Parabens
Propylparaben
Propylparaben sodium