Methylparaben sodium

Methylparaben sodium structural formula

CAS Number 5026-62-0
Molecular Formula C8H7NaO3
Molecular Weight 174.131 g/mol
LogP 1.24
  • Methylparaben sodium
  • Sodium 4-(methoxycarbonyl)phenolate
  • Benzoic acid, 4-hydroxy-, methyl ester, sodium salt (1:1)
  • 5026-62-0
  • Benzoic acid, 4-hydroxy-, methyl ester, sodium salt
  • 4-(Methoxycarbonyl)phenolate de sodium
  • 4-(metoxicarbonil)fenolato de sodio
  • 4-Hydroxybenzoic acid methyl ester sodium salt
  • Benzoic acid, 4-hydroxy-, methyl ester, sodium salt (1:1)
  • Benzoic acid, p-hydroxy-, methyl ester, sodium salt
  • Bonomold OMNa
  • Methyl 4-hydroxybenzoate sodium salt
  • Methyl p-hydroxybenzoate sodium salt
  • Natrium-4-(methoxycarbonyl)phenolat
  • p-Hydroxybenzoic acid methyl ester sodium salt
  • Preserval MS
  • sodium 4-(methoxycarbonyl)phenolate
  • Sodium 4-(methoxycarbonyl)phenoxide
  • Sodium 4-carbomethoxyphenolate
  • Sodium methyl 4-hydroxybenzoate
  • Sodium methyl p-hydroxybenzoate
  • Sodium methyl-4-hydroxybenzoate
  • Sodium methylparaben
  • Sodium p-methoxycarbonylphenoxide
  • Sodium, (p-carboxyphenoxy)-, methyl ester
  • Solparol
  • EINECS 225-714-1
  • Methyl p-hydroxybenzoate, sodium salt


Separation of Methylparaben sodium on Newcrom R1 HPLC column

Methylparaben sodium can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Separation of Methylparaben sodium on Newcrom C18 HPLC column
Newcrom R1

This column is available in new type of hardware with only one connection end. Learn more about performance and advantage of this new hardware.

Application Analytes:

Methylparaben sodium

HPLC Separation of Mixture of Carbocisteine, Methylparaben & Propylparaben on Primesep 100 Column
Carbocysteine is a medication that reduces the viscosity of mucus making it easier to cough up. Methylparaben and propylparaben are used as preservatives in cosmetics, pharmaceuticals and food. They can be separated in HPLC on a Primesep 100 mixed-mode column by both hydrophobic and ionic properties present on the stationary phase. The analytical method uses acetonitrile (ACN) gradient and water with sulfuric acid (H2SO4) as buffer and UV detected at 200nm.


Column Primesep 100, 4.6x150 mm, 5 µm, 100A
Mobile Phase Gradient MeCN  - 2-50%, 20 min
Buffer H2SO4 - 0.05 %
Flow Rate 1.0 ml/min
Detection UV, 200 nm


Class of Compounds Drug,  Acid, Hydrophilic, Ionizable, Carboxylic acid, Carbocyclic, Benzoate, Hydroxy Acid, Amino Acid, Hydroxybenzoate, Phenol
Analyzing Compounds Carbocisteine, Methylparaben, Propylparaben

Application Analytes:

Methylparaben sodium
Propylparaben sodium

Follow by Email