Metoprolol

Metoprolol structural formula

UV Spectra of Metoprolol

UV Metoprolol spectra

 

 

 

CAS Number51384-51-1
Molecular FormulaC15H25NO3
Molecular Weight267.369
InChI KeyIUBSYMUCCVWXPE-UHFFFAOYSA-N
LogP1.88
Synonyms
  • Metoprolol
  • 1-[4-(2-Methoxyethyl)phenoxy]-3-[(propan-2-yl)amino]propan-2-ol
  • 2-Propanol, 1-[4-(2-methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-
  • 51384-51-1
  • 2-Propanol, 1-[4-(2-methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-
  • (.+-.)-Metoprolol
  • (RS)-Metoprolol
  • 1-(isopropilamino)-3-[4-(2-metoxietil)fenoxi]propan-2-ol
  • 1-(isopropylamino)-3-[4-(2-methoxyethyl)phenoxy]propan-2-ol
  • 1-(isopropylamino)-3-[4-(2-methoxyethyl)phenoxy]propane-2-ol
  • 1-[4-(2-Methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-2-propanol
  • 1-Isopropylamino-3-[4-(2-methoxyethyl)phenoxy]-2-propanol
  • Beatrolol
  • dl-Metoprolol
  • Meijoprolol
  • Metocard
  • Metohexal
  • Seroken
  • Spesicor
  • EINECS 257-166-4
  • UNII-GEB06NHM23
  • Neobloc
  • Loresor
  • (+/-)-Metoprolol
  • Lopresor
  • Lopresoretic
  • Lopressor
  • Metoprolol succinate
  • Metoprolol tartrate
  • Metoprololum
  • Preblok
  • Presolol
  • Seloken
  • Toprol-XL
  • {2-hydroxy-3-[4-(2-methoxyethyl)phenoxy]propyl}(propan-2-yl)amine
  • 37350-58-6
  • 54163-88-1

Applications:

HPLC Method for Analysis of Metoprolol in Tablets on Primesep 200 Column

June 29, 2018

HPLC Method for Metoprolol on Primesep 200 by SIELC Technologies


HPLC Method for Analysis of Metoprolol

High Performance Liquid Chromatography (HPLC) Method for Analysis of Metoprolol 

Metoprolol is a beta-blocker that is used to treat high blood pressure, angina, and heart failure by blocking beta-1 adrenergic receptors. At it’s most effective, it can lower the risk of death after a heart attack.

Metoprolol can be retained and analyzed using the Primesep 200 stationary phase column. The analysis utilizes an isocratic method with a simple mobile phase consisting of water and acetonitrile (MeCN) with a phosphoric acid buffer. Detection is performed using UV.

Condition
Column Primesep 200, 4.6 x 150 mm, 5 µm, 100 A, dual ended
Mobile Phase MeCN/H2O – 50/50%
Buffer H3PO4 – 0.5 %
Flow Rate 1.0 ml/min
Detection UV, 223 nm

Description
Class of Compounds
 Drug, Beta-blocker, Hydrophobic, Basic
Analyzing Compounds Metoprolol

Application Column

Primesep 200

Column Diameter: 4.6 mm
Column Length: 150 mm
Particle Size: 5 µm
Pore Size: 100 A
Column options: dual ended

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Application Analytes:
Metoprolol
Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.