Pantoprazole sodium

CAS Number	138786-67-1
Molecular Formula	C16H14F2N3NaO4S
Molecular Weight	405.351 g/mol
InChI Key	YNWDKZIIWCEDEE-UHFFFAOYSA-N
LogP	1.38
Synonyms	Pantoprazole sodium Sodium 5-(difluoromethoxy)-2-[(3,4-dimethoxypyridin-2-yl)methanesulfinyl]benzimidazol-1-ide 1H-Benzimidazole, 5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-, sodium salt (1:1) 138786-67-1 5-(Difluoromethoxy)-2-(((3,4-dimethoxy-2-pyridinyl)methyl)sulfinyl)-1H-benzimidazole sodium Controloc Pantoloc Protonix I.V. Protonix IV Protonix delayed-release Pantecta UNII-S9363155XL Protonix DR

Applications:

HPLC Method for Analysis of Pantoprazole Sodium in Tablets on Newcrom R1

Condition
Column	Newcrom R1 4.6x100 mm, 5 µm, 100A
Mobile Phase	MeCN/H2O - 25/75%
Buffer	TEAPh - 10 mM
Flow Rate	1.0ml/min
Detection	UV, 290 nm

Description
Class of Compounds	Drug, Proton-pump inhibitor, Hydrophobic, Neutral
Analyzing Compounds	Pantoprazole

Pantoprazole
Pantoprazole sodium

Determination Pantoprazole on Obelisc R Column

Separation type: Liquid Chromatography Ion Exclusion

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High Performance Liquid Chromatography (HPLC) Method of Pantoprazole. Pantoprazole, a drug from the proton pump inhibitors (PPIs) group, is widely used for treatment of gastroesophageal disease and peptic ulcer. It can be retained on an Obelisc R column, which has both positive and negative ion-pairs embedded in the stationary phase, allowing for the fine tuning and separation of a wide range of compounds with different ionic properties. Pantoprazole can be determined isocratically using a simple MS-compatible mobile phase of acetonitrile (ACN) and water with Ammonium Acetate (AmAc) buffer and detected by UV at 290nm, ELSD, CAD or LC/MS.

Condition
Column	Obelisc R, 4.6x150 mm, 5 µm, 100A
Mobile Phase	MeCN -35%
Buffer	Ammonium Acetate pH 5.5 - 10 mM
Flow Rate	1.0 ml/min
Detection	UV 290 nm

Description
Class of Compounds	Drug
Analyzing Compounds	Pantoprazole