Pantoprazole sodium

Pantoprazole sodium structural formula

CAS Number138786-67-1
Molecular FormulaC16H14F2N3NaO4S
Molecular Weight405.351
InChI KeyYNWDKZIIWCEDEE-UHFFFAOYSA-N
LogP1.38
Synonyms
  • Pantoprazole sodium
  • Sodium 5-(difluoromethoxy)-2-[(3,4-dimethoxypyridin-2-yl)methanesulfinyl]benzimidazol-1-ide
  • 1H-Benzimidazole, 5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-, sodium salt (1:1)
  • 138786-67-1
  • 5-(Difluoromethoxy)-2-(((3,4-dimethoxy-2-pyridinyl)methyl)sulfinyl)-1H-benzimidazole sodium
  • Controloc
  • Pantoloc
  • Protonix I.V.
  • Protonix IV
  • Protonix delayed-release
  • Pantecta
  • UNII-S9363155XL
  • Protonix DR

Applications:

Determination Pantoprazole on Obelisc R Column

February 11, 2021

Separation type: Liquid Chromatography Ion Exclusion




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High Performance Liquid Chromatography (HPLC) Method of Pantoprazole.

Pantoprazole, a drug from the proton pump inhibitors (PPIs) group, is widely used for treatment of gastroesophageal disease and peptic ulcer. It can be retained on an Obelisc R column, which has both positive and negative ion-pairs embedded in the stationary phase, allowing for the fine tuning and separation of a wide range of compounds with different ionic properties. Pantoprazole can be determined isocratically using a simple MS-compatible mobile phase of acetonitrile (ACN) and water with Ammonium Acetate (AmAc) buffer and detected by UV at 290nm, ELSD, CAD or LC/MS.



 

Condition

Column Obelisc R, 4.6×150 mm, 5 µm, 100A
Mobile Phase MeCN -35%
Buffer Ammonium Acetate  pH 5.5 – 10 mM
Flow Rate 1.0 ml/min
Detection UV 290 nm

 

Description

Class of Compounds
 Drug
Analyzing Compounds Pantoprazole

 

Application Column

Obelisc R

SIELC has developed the Obelisc™ columns, which are mixed-mode and utilize Liquid Separation Cell technology (LiSC™). These cost-effective columns are the first of their kind to be commercially available and can replace multiple HPLC columns, including reversed-phase (RP), AQ-type reversed-phase, polar-embedded group RP columns, normal-phase, cation-exchange, anion-exchange, ion-exclusion, and HILIC (Hydrophilic Interaction Liquid Chromatography) columns. By controlling just three orthogonal method parameters - buffer concentration, buffer pH, and organic modifier concentration - users can adjust the column properties with pinpoint precision to separate complex mixtures.

Select options
Application Analytes:
Pantoprazole
Pantoprazole sodium
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

HPLC Method for Analysis of Pantoprazole Sodium in Tablets on Newcrom R1

June 8, 2018

Pantoprazole Sodium in Tablets

 

Condition

Column Newcrom R1  4.6×100 mm, 5 µm, 100A
Mobile Phase MeCN/H2O – 25/75%
Buffer TEAPh – 10 mM
Flow Rate 1.0ml/min
Detection UV, 290 nm

 

Description

Class of Compounds
Drug, Proton-pump inhibitor, Hydrophobic, Neutral
Analyzing Compounds Pantoprazole

 

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

Select options
Application Analytes:
Pantoprazole
Pantoprazole sodium
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.