Pantoprazole sodium

CAS Number 138786-67-1
Molecular Formula C16H14F2N3NaO4S
Molecular Weight 405.351 g/mol
InChI Key YNWDKZIIWCEDEE-UHFFFAOYSA-N
LogP 1.38
Synonyms
  • Pantoprazole sodium
  • Sodium 5-(difluoromethoxy)-2-[(3,4-dimethoxypyridin-2-yl)methanesulfinyl]benzimidazol-1-ide
  • 1H-Benzimidazole, 5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-, sodium salt (1:1)
  • 138786-67-1
  • 5-(Difluoromethoxy)-2-(((3,4-dimethoxy-2-pyridinyl)methyl)sulfinyl)-1H-benzimidazole sodium
  • Controloc
  • Pantoloc
  • Protonix I.V.
  • Protonix IV
  • Protonix delayed-release
  • Pantecta
  • UNII-S9363155XL
  • Protonix DR

Applications:


HPLC Method for Analysis of Pantoprazole Sodium in Tablets on Newcrom R1
Pantoprazole Sodium in Tablets  

Condition

Column Newcrom R1  4.6x100 mm, 5 µm, 100A
Mobile Phase MeCN/H2O - 25/75%
Buffer TEAPh - 10 mM
Flow Rate 1.0ml/min
Detection UV, 290 nm
 

Description

Class of Compounds Drug, Proton-pump inhibitor, Hydrophobic, Neutral
Analyzing Compounds Pantoprazole
 

Application Analytes:

Pantoprazole
Pantoprazole sodium

Determination Pantoprazole on Obelisc R Column
Separation type: Liquid Chromatography Ion Exclusion

HPLC.cloud View on hplc.cloud



High Performance Liquid Chromatography (HPLC) Method of Pantoprazole. Pantoprazole, a drug from the proton pump inhibitors (PPIs) group, is widely used for treatment of gastroesophageal disease and peptic ulcer. It can be retained on an Obelisc R column, which has both positive and negative ion-pairs embedded in the stationary phase, allowing for the fine tuning and separation of a wide range of compounds with different ionic properties. Pantoprazole can be determined isocratically using a simple MS-compatible mobile phase of acetonitrile (ACN) and water with Ammonium Acetate (AmAc) buffer and detected by UV at 290nm, ELSD, CAD or LC/MS.

 

Condition

Column Obelisc R, 4.6x150 mm, 5 µm, 100A
Mobile Phase MeCN -35%
Buffer Ammonium Acetate  pH 5.5 - 10 mM
Flow Rate 1.0 ml/min
Detection UV 290 nm
 

Description

Class of Compounds  Drug
Analyzing Compounds Pantoprazole
 

Application Analytes:

Pantoprazole
Pantoprazole sodium