|Molecular Weight||368.474 g/mol|
Perindopril can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.
Perindopril is an ACE inhibitor used in treating hypertension (high blood pressure). It comes in tablet form. Perindopril can be retained on a Primesep 200 column in under 8 minutes with a simple isocratic mobile phase and sulphuric acid buffer. Primesep 200 is a reverse-phase (RP) mixed-mode column with embedded weak acidic ion-pairing groups
Column Primesep 200, 4.6x150 mm, 5 µm, 100A Mobile Phase MeCN/H2O - 20/80% Buffer H2SO4 - 0.4 % Flow Rate 1.0 ml/min Detection UV, 205 nm
Class of Compounds Drug, Acid, Hydrophobic, Ionizable Analyzing Compounds PerindoprilApplication Analytes: