Perindopril

CAS Number 82834-16-0
Molecular Formula C19H32N2O5
Molecular Weight 368.474 g/mol
InChI Key IPVQLZZIHOAWMC-QXKUPLGCSA-N
LogP 2.13
Synonyms
  • Perindopril
  • (2S,3aS,7aS)-1-[(2S)-2-{[(2S)-1-Ethoxy-1-oxopentan-2-yl]amino}propanoyl]octahydro-1H-indole-2-carboxylic acid (non-preferred name)
  • 82834-16-0
  • BRN 4300272
  • Perindoprilum
  • UNII-Y5GMK36KGY
  • (2S,3aS,7aS)-1-[(2S)-2-{[(2S)-1-ethoxy-1-oxopentan-2-yl]amino}propanoyl]octahydro-1H-indole-2-carboxylic acid

Applications:


Separation of Perindopril on Newcrom R1 HPLC column
Separation of Perindopril on Newcrom C18 HPLC column

Perindopril can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.



Application Analytes:

Perindopril

HPLC Determination of Perindopril on Primesep 200 column
HPLC Determination of Perindopril
Perindopril is an ACE inhibitor used in treating hypertension (high blood pressure). It comes in tablet form. Perindopril can be retained on a Primesep 200 column in under 8 minutes with a simple isocratic mobile phase and sulphuric acid buffer. Primesep 200 is a reverse-phase (RP) mixed-mode column with embedded weak acidic ion-pairing groups
 

Condition

Column Primesep 200, 4.6x150 mm, 5 µm, 100A
Mobile Phase MeCN/H2O - 20/80%
Buffer H2SO4 - 0.4 %
Flow Rate 1.0 ml/min
Detection UV, 205 nm
 

Description

Class of Compounds Drug, Acid, Hydrophobic, Ionizable
Analyzing Compounds Perindopril
 

Application Analytes:

Perindopril