Pentadecafluorooctanoic acid (PFOA)

PFOA structural formula

CAS Number 335-67-1
Molecular Formula C8HF15O2
Molecular Weight 414.070 g/mol
LogP 5.68
  • PFOA
  • Pentadecafluorooctanoic acid
  • Octanoic acid, 2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-pentadecafluoro-
  • 335-67-1
  • Perfluorooctanoic acid
  • Perfluorooctanoic acid (PFOA)
  • Octanoic acid, pentadecafluoro-
  • Acide pentadecafluorooctanoique
  • acido pentadecafluorooctanoico
  • Eftop EF 201
  • n-Perfluorooctanoic acid
  • NSC 95114
  • Octanoic acid, 2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-pentadecafluoro-
  • Pentadecafluoro-1-octanoic acid
  • Pentadecafluoroctansaure
  • Pentadecafluoro-n-octanoic acid
  • pentadecafluorooctanoic acid
  • Perfluoro-1-heptanecarboxylic acid
  • Perfluorocaprylic acid
  • Perfluoroheptanecarboxylic acid
  • BRN 1809678
  • EINECS 206-397-9
  • Hexanoyl fluoride, 3,3,4,4,5,5,6,6,6-nonafluoro-2-oxo-
  • Perfluoroctanoic acid
  • UNII-947VD76D3L
  • 2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-pentadecafluorooctanoic acid
  • perfluoro-n-octanoic acid
  • perfluoroheptanecarboxylic acid
  • perfluorooctylcarboxylic acid
  • 65618-66-8
  • 71244-15-0


HPLC Determination of Pentadecafluorooctanoic acid (PFOA) on Newcrom R1 Column
HPLC Determination of Pentadecafluorooctanoic acid on Newcrom R1 Column  


Column Newcrom R1, 4.6x150 mm, 5 µm, 100A
Mobile Phase MeCN/H2O - 60/40%
Buffer H2SO4 - 0.4%
Flow Rate 1.0 ml/min
Detection UV, 220 nm


Class of Compounds Acid, Hydrophobic
Analyzing Compounds Pentadecafluorooctanoic acid

Application Analytes:

Pentadecafluorooctanoic acid (PFOA)

Separation of PFOA on Newcrom R1 HPLC column

PFOA can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Separation of PFOA on Newcrom R1 HPLC column
Newcrom R1

This column is available in new type of hardware with only one connection end. Learn more about performance and advantage of this new hardware.

Application Analytes:

Pentadecafluorooctanoic acid (PFOA)

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