Procainamide

Procainamide structural formula

CAS Number 51-06-9
Molecular Formula C13H21N3O
Molecular Weight 235.331 g/mol
InChI Key REQCZEXYDRLIBE-UHFFFAOYSA-N
LogP 0.88
Synonyms
  • Procainamide
  • 4-Amino-N-[2-(diethylamino)ethyl]benzamide
  • Benzamide, 4-amino-N-[2-(diethylamino)ethyl]-
  • 51-06-9
  • 4-14-00-01154
  • Benzamide, 4-amino-N-[2-(diethylamino)ethyl]-
  • 4-Amino-N-(diethylaminoethyl)benzamide
  • 4-Amino-N-[2-(diethylamino)ethyl]benzamide
  • Benzamide, p-amino-N-[2-(diethylamino)ethyl]-
  • Novocainamid
  • Novocainamide
  • Novocaine amide
  • Novocamid
  • NSC 27461
  • p-Aminobenzoic diethylaminoethylamide
  • p-Amino-N-(2-diethylaminoethyl)benzamide
  • Procainamid
  • procainamida
  • Procaine amide
  • Procanbid
  • 4-Amino-N-(2-(diethylamino)ethyl)benzamide
  • Benzamide, 4-amino-N-(2-(diethylamino)ethyl)-
  • Biocoryl
  • BRN 2214285
  • EINECS 200-078-8
  • Procamide
  • 2-Diethylaminoethylamid kyseliny p-aminobenzoove
  • Procainamidum
  • UNII-L39WTC366D
  • Rhythmin

Applications:

USP Methods for the Separation of Propranolol and Procainamide using a Legacy L1 Column

 

Application Notes:
Propranolol is a common beta-blocker used for treating anxiety and hypertension, and procainamide is an antiarrhythmic drug. According to the USP methods, propranolol hydrochloride contain no less than 98% and no more than 101.5 percent of propranolol calculated on a dried basis. The USP HPLC method for the separation of phenylephrine and epinephrine was developed on Legacy L1 column according to the US Pharmacopeia methodology. L1 classification is assigned to reversed-phase HPLC column containing C18 ligand. Support for the material is spherical silica gel with particles size 3-10 um and pore size of 100-120A. Resolution between critical pairs corresponds to rules and specifications of USP.

Application Columns: Legacy L1 C18 HPLC column

Application compounds: Propranolol and procainamide

Mobile phase: Water/MeOH/MeCN (70/70/90) with 7mM sodium lauryl sulfate and 11 mM phosphoric acid

Detection technique: UV

Reference: USP35: NF30


Application Analytes:

Procainamide
Propranolol
USP Methods for the Separation of Propranolol and Procainamide Using the Legacy L1 Column

 

Application Notes:
Propranolol is a common beta-blocker used for treating anxiety and hypertension, and procainamide is an antiarrhythmic drug. According to the USP methods, propranolol hydrochloride contain no less than 98% and no more than 101.5 percent of propranolol calculated on a dried basis. The USP HPLC method for the separation of phenylephrine and epinephrine was developed on Legacy L1 column according to the US Pharmacopeia methodology. L1 classification is assigned to reversed-phase HPLC column containing C18 ligand. Support for the material is spherical silica gel with particles size 3-10 um and pore size of 100-120A. Resolution between critical pairs corresponds to rules and specifications of UPS.

Reference: USP35: NF30


Application Analytes:

Procainamide
Propranolol
USP Methods for the Analysis of Procainamide

 

Application Notes: Procainamide is a common antiarrhythmic agent used to treat cardiac arrhythmias. According to USP methods procainamide hydrochloride contains not less than 98% and no more than 102% procainamide based on the dried basis. The USP HPLC method for the separation of procainamide and 4-aminobenzoic was developed on Legacy L1 column according to the US Pharmacopeia methodology. L1 classification is assigned to reversed-phase HPLC column containing C18 ligand. Support for the material is spherical silica gel with particles size 3-10 um and pore size of 100-120A. Resolution between critical pairs corresponds to rules and specifications of UPS.

Reference: USP 35- NF30


Application Analytes:

4-Aminobenzoic Acid
Procainamide