Propylparaben sodium

Propylparaben sodium structural formula

CAS Number 35285-69-9
Molecular Formula C10H11NaO3
Molecular Weight 202.185 g/mol
LogP 2.17
  • Propylparaben sodium
  • Sodium 4-(propoxycarbonyl)phenolate
  • Benzoic acid, 4-hydroxy-, propyl ester, sodium salt (1:1)
  • 35285-69-9
  • Caswell No. 714A
  • EINECS 252-488-1
  • EPA Pesticide Chemical Code 061204
  • Propyl p-hydroxybenzoate, sodium salt
  • Natrium propyl 4-hydroxybenzoat
  • Propyl-4-hydroxybenzoat natriumsalz
  • UNII-625NNB0G9N
  • Propyl 4-hydroxybenzoate sodium salt
  • Sodium propyl hydroxybenzoate


Separation of Propylparaben sodium on Newcrom R1 HPLC column

Propylparaben sodium can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Separation of Propylparaben sodium on Newcrom C18 HPLC column
Newcrom R1

This column is available in new type of hardware with only one connection end. Learn more about performance and advantage of this new hardware.

Application Analytes:

Propylparaben sodium

HPLC Separation of Mixture of Carbocisteine, Methylparaben & Propylparaben on Primesep 100 Column
Carbocysteine is a medication that reduces the viscosity of mucus making it easier to cough up. Methylparaben and propylparaben are used as preservatives in cosmetics, pharmaceuticals and food. They can be separated in HPLC on a Primesep 100 mixed-mode column by both hydrophobic and ionic properties present on the stationary phase. The analytical method uses acetonitrile (ACN) gradient and water with sulfuric acid (H2SO4) as buffer and UV detected at 200nm.


Column Primesep 100, 4.6x150 mm, 5 µm, 100A
Mobile Phase Gradient MeCN  - 2-50%, 20 min
Buffer H2SO4 - 0.05 %
Flow Rate 1.0 ml/min
Detection UV, 200 nm


Class of Compounds Drug,  Acid, Hydrophilic, Ionizable, Carboxylic acid, Carbocyclic, Benzoate, Hydroxy Acid, Amino Acid, Hydroxybenzoate, Phenol
Analyzing Compounds Carbocisteine, Methylparaben, Propylparaben

Application Analytes:

Methylparaben sodium
Propylparaben sodium

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