Ractopamine hydrochloride

CAS Number 90274-24-1
Molecular Formula C18H24ClNO3
Molecular Weight 337.840 g/mol
InChI Key JHGSLSLUFMZUMK-UHFFFAOYSA-N
LogP 1.92
Synonyms
  • Ractopamine hydrochloride
  • 4-(1-Hydroxy-2-{[4-(4-hydroxyphenyl)butan-2-yl]amino}ethyl)phenol--hydrogen chloride (1/1)
  • Benzenemethanol, 4-hydroxy-alpha-[[[3-(4-hydroxyphenyl)-1-methylpropyl]amino]methyl]-, hydrochloride (1:1)
  • 90274-24-1
  • Benzenemethanol, 4-hydroxy-alpha-(((3-(4-hydroxyphenyl)-1-methylpropyl)amino)methyl)-, hydrochloride
  • Ractopamine HCl
  • UNII-309G9J93TP
  • Optaflexx 45

Applications:


Separation of Ractopamine hydrochloride on Newcrom R1 HPLC column
Separation of Ractopamine hydrochloride on Newcrom C18 HPLC column

Ractopamine hydrochloride can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.



Application Analytes:

Ractopamine hydrochloride

HPLC Determination of Ractopamine on Primesep 100 Column
Ractopamine is a livestock feed additive designed to promote muscle synthesis and leanness. It is banned in many countries, excluding the US, Canada and Mexico. It can be retained on a Primesep 100 Column in about 7 minutes. Primesep 100 is a reverse-phase (RP) mixed-mode column with embedded acidic ion-pairing groups.
 

Condition

Column Primesep 100, 4.6x150 mm, 5 µm, 100A
Mobile Phase MeCN/H2O - 20/80%
Buffer H2SO4 - 0.3 %
Flow Rate 1.0 ml/min
Detection UV, 222 nm
 

Description

Class of Compounds Drug, Basic, Hydrophobic, Ionizable, Amine
Analyzing Compounds Ractopamine
 

Application Analytes:

Ractopamine hydrochloride