|Molecular Weight||287.360 g/mol|
Ritodrine can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.
Ritodrine (also Yutopar), is a drug used in relaxation of smooth muscle and to stop premature labor. It has been pulled from the US market due to its side effects. Ritodrine can be retained on a Primesep 100 column with great peak shape using isocratic method of 30/70 Acetonitrile (ACN) and water with 0.3% sulfuric acid as buffer. UV Detection 276nm.
Column Primesep 100, 4.6x150 mm, 5 µm, 100A Mobile Phase MeCN/H2O - 30/70% Buffer H2SO4 - 0.3 % Flow Rate 1.0 ml/min Detection UV, 276 nm
Class of Compounds Drug, Basic, Hydrophobic, Ionizable, Amine Analyzing Compounds RitodrineApplication Analytes: