Ritodrine

CAS Number 26652-09-5
Molecular Formula C17H21NO3
Molecular Weight 287.360 g/mol
InChI Key IOVGROKTTNBUGK-SJCJKPOMSA-N
LogP 1.63
Synonyms
  • Ritodrine
  • 4-[(1R,2S)-1-Hydroxy-2-{[2-(4-hydroxyphenyl)ethyl]amino}propyl]phenol
  • Benzenemethanol, 4-hydroxy-alpha-[(1S)-1-[[2-(4-hydroxyphenyl)ethyl]amino]ethyl]-, (alphaR)-
  • 26652-09-5
  • Benzenemethanol, 4-hydroxy-?-[(1R)-1-[[2-(4-hydroxyphenyl)ethyl]amino]ethyl]-, (?S)-rel-
  • (.+-.)-Ritodrine
  • (R*,S*)-4-Hydroxy-?-[1-[2-(4-hydroxyphenylethyl)amino]ethyl]benzenemethanol
  • Benzenemethanol, 4-hydroxy-?-[1-[[2-(4-hydroxyphenyl)ethyl]amino]ethyl]-, (R*,S*)-
  • Benzyl alcohol, p-hydroxy-?-[1-[(p-hydroxyphenethyl)amino]ethyl]-, erythro-
  • Ritodrin
  • ritodrina
  • Benzyl alcohol, p-hydroxy-alpha-(1-((p-hydroxyphenethyl)amino)ethyl)-, erythro-
  • BRN 2388728
  • EINECS 247-879-9
  • erythro-p-Hydroxy-alpha-(1-((p-hydroxyphenethyl)amino)ethyl)benzyl alcohol
  • 4-Hydroxy-alpha-(1-((2-(4-hydroxyphenyl)ethyl)amino)ethyl)benzenemethanol (R*,S*)-
  • Ritodrinium
  • p-Hydroxy-alpha-(1-((p-hydroxyphenethyl)amino)ethyl)benzyl alcohol
  • 2-(4-Hydroxyphenethylamino)-1-(4-hydroxyphenyl)propanol
  • UNII-I0Q6O6740J

Applications:


Separation of Ritodrine on Newcrom R1 HPLC column
Separation of Ritodrine on Newcrom R1 HPLC column

Ritodrine can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.



Application Analytes:

Ritodrine

HPLC Determination of Ritodrine on Primesep 100
HPLC Determination of Ritodrine_1181
Ritodrine (also Yutopar), is a drug used in relaxation of smooth muscle and to stop premature labor. It has been pulled from the US market due to its side effects. Ritodrine can be retained on a Primesep 100 column with great peak shape using isocratic method of 30/70 Acetonitrile (ACN) and water with 0.3% sulfuric acid as buffer. UV Detection 276nm.
 

Condition

Column Primesep 100, 4.6x150 mm, 5 µm, 100A
Mobile Phase MeCN/H2O - 30/70%
Buffer H2SO4 - 0.3 %
Flow Rate 1.0 ml/min
Detection UV, 276 nm
 

Description

Class of Compounds Drug, Basic, Hydrophobic, Ionizable, Amine
Analyzing Compounds Ritodrine
 

Application Analytes:

Ritodrine