Sodium dodecyl sulfate

Sodium dodecyl sulfate structural formula

CAS Number151-21-3
Molecular FormulaC12H25NaO4S
Molecular Weight288.380
InChI KeyDBMJMQXJHONAFJ-UHFFFAOYSA-M
LogP1.60
Synonyms
  • SDS
  • Sodium dodecyl sulfate
  • Sulfuric acid, dodecyl ester, sodium salt (1:1)
  • 151-21-3
  • Sodium lauryl sulfate
  • SDS
  • Alkyl sulfate esters-AS
  • Sulfuric acid monododecyl ester sodium salt
  • 1-Dodecanol,hydrogen sulfate,sodium salt
  • Adeka Hope LS 35
  • Adeka Hope LS 90
  • Akyposal NLS
  • Akyposal SDS
  • Alscoap LN 40A
  • Alscoap LN 90
  • Alscoap LN-140
  • Alscoap MP 90N
  • Alscoap SP 40
  • Alscoap-LN 90P
  • Aquarex Me
  • Avirol SL 2010
  • Bio-Soft SDBS 60
  • Calfoam ES 303
  • Calfoam SLS 30
  • Carsonol SLS-S
  • Colonial SLS
  • Cycloryl 21LS
  • Cycloryl 580
  • Dehydag Sulfate GL
  • Dermacide
  • DODECYL HYDROGEN SULFATE SODIUM SALT
  • DODECYL HYDROGENSULFATE SODIUM SALT
  • Dodecyl sodium sulfate
  • DODECYL SULFATE SODIUM SALT
  • DODECYL SULFATE, SODIUM
  • Duponol C
  • Duponol ME
  • Duponol methyl dry
  • Duponol QC
  • Duponol WA
  • Duponol WA Dry
  • Duponol WAQ
  • Duponol WAQE
  • Duponol WAQM
  • Emal 10 Needle
  • Emal 2F Needle
  • Emal OS
  • Empicol 0303
  • Empicol 0303VA
  • Empicol BSD 70
  • Empicol LPZ
  • Empicol LS 30
  • Empicol LX 2
  • Empicol LX 28
  • Empicol LX 28R
  • Empicol LX 42
  • Empicol LXSV 938U
  • Empicol LXSV/S
  • Empicol LXV
  • Empicol LY 28S
  • Empicol LZ/D
  • Empimin SDS
  • Emulsogen LS
  • Equex S
  • Equex SP
  • Equex STM Paste
  • Finasol OSR 2
  • Fluka 71730
  • Fongrapol LSS
  • Gardinol
  • Gardinol type detergent
  • Gardinol type detergents
  • Genapol LSS
  • Kieselguhr, soda ash flux-calcined
  • Lanette Wax S
  • LAURYL ESTER SULFATE, SODIUM
  • Lauryl sodium sulfate
  • Lauryl sulfate sodium
  • Lauryl sulfate sodium salt
  • LAURYL SULFATE-SODIUM SALT
  • LAURYLSULFATE, SODIUM SALT
  • Maprofix 563
  • Maprofix LK
  • Maprofix Neu
  • Maprofix WAC
  • Maprofix WAC-LA
  • Melanol CL
  • Melanol CL 30
  • Monododecyl sodium sulfate
  • Monogen LH
  • Monogen Y 100
  • Monogen Y 500
  • Montopol La Paste
  • Natriumdodecylsulfat
  • NATRIUM-LAURYL-SULFAT
  • n-Dodecyl sulfate sodium
  • Neutrazyme
  • Newkalgen LX-C
  • Nikkol SLS
  • Nissan Persoft SP
  • Nissan Sintrex L 100
  • Octosol SLS
  • Odoripon Al 95
  • Orvus WA
  • Orvus WA Paste
  • P and G Emulsifier 104
  • Perlankrol L
  • Pionin A 21
  • Polystep B 3
  • Polystep B 5
  • Quolac EX-UB
  • Rewopol NLS 28
  • Rewopol NLS 30
  • Rhodapon LCP
  • Rhodapon LSB
  • Rhodapon SB
  • Rhodapon SB 8208S
  • Rhodapon SM
  • Rhodapon UB
  • Richonol A
  • Rolpon LS
  • Rosulfan L 1
  • Sandet ONA
  • Silipon RN 6031
  • Sinnopon LS 100
  • Sinnopon LS 95
  • Sinolin 90TK-N
  • Sintapon L
  • Sintrex L 100
  • Sipex OP
  • Sipex SB
  • Sipex UB
  • Sipon LCS 98
  • Sipon LS
  • Sipon LS 100
  • Sipon LSB
  • Sipon PD
  • Sipon UB
  • Sipon WD
  • Sodium dedecylsulfate
  • sodium dodecyl sulphate
  • Sodium dodecylsulfate
  • SODIUM LAURYL (2MOLE) ETHER SULFATE NATURAL BASE
  • Sodium lauryl sulphate
  • Sodium monolauryl sulfate
  • Sodium n-dodecyl sulfate
  • sodiumdodecyl sulphate
  • SODIUM-LAURYLSULFATE, SODIUM SALT
  • Sorpol 5029O
  • Sorpol 8070
  • Standapol WAQ
  • Standapol WAQ Special
  • Standapol WAQ-LC
  • Stanfax 234
  • Steinapol NLS
  • Steinapol NLS 90
  • Stepanal WAC
  • Stepanol ME
  • Stepanol ME Dry AW
  • Stepanol ME Dry SLS
  • Stepanol ME-Dry
  • Stepanol T 28
  • Stepanol WA
  • Stepanol WA 100
  • Stepanol WA Paste
  • Stepanol WA Special
  • Stepanol WAC
  • Sterling WAQ-CH
  • Sulfate de sodium et de dodecyle
  • sulfato de sodio y dodecilo
  • Sulfetal L 95
  • Sulfochem SLS
  • Sulfolyser
  • Sulfopon T 30
  • Sulfopon WA 1 Special
  • Sulfopon WA 2
  • Sulfopon WA 3
  • Sulfuric acid dodecyl ester sodium salt
  • Sulfuric acid monododecyl ester sodium salt (1:1)
  • Sulfuric acid, monododecyl ester, sodium salt
  • Sunnol LM 1130
  • Supralate C
  • Surfactant K12
  • Syntapon L
  • Taycalite N 2030
  • Texapon K 12
  • Texapon K 12/15
  • Texapon K 1296
  • Texapon K 1298
  • Texapon K 12G
  • Texapon K 12P
  • Texapon L 100
  • Texapon ZHC
  • Trepenol WA
  • Ufarol AM 30
  • Ufarol TCL 92
  • Witcolate A
  • Witcolate WAC-LA
  • Anticerumen
  • Aquarex methyl
  • Carsonol SLS
  • Carsonol SLS Paste B
  • Carsonol SLS Special
  • Caswell No. 779
  • Conco sulfate WA
  • Conco sulfate WA-1200
  • Conco sulfate WA-1245
  • Conco Sulfate WAG
  • Conco Sulfate WAN
  • Conco Sulfate WAS
  • Conco sulfate WN
  • Cycloryl 21
  • Cycloryl 31
  • Cycloryl 585N
  • Dehydag sulfate GL emulsion
  • Dehydag sulphate GL emulsion
  • Dehydrag sulfate gl emulsion
  • Detergent 66
  • Dodecyl alcohol, hydrogen sulfate, sodium salt
  • Dodecyl sulfate sodium
  • Dodecyl sulfate, sodium salt
  • Dupanol WAQ
  • Duponal
  • Duponal WAQE
  • Duponol
  • Duponol methyl
  • Duponol QX
  • Duponol WAQA
  • EINECS 205-788-1
  • Emersal 6400
  • Emulsifier No. 104
  • EPA Pesticide Chemical Code 079011
  • Finasol osr2
  • Finasol osr(sub 2)
  • Hexamol SLS
  • Incronol SLS
  • Jordanol SL-300
  • Lanette wax-S
  • Lauryl sulfate, sodium salt
  • Lauyl sodium sulfate
  • Maprobix NEU
  • Monagen Y 100
  • NCI-C50191
  • NSC 402488
  • Perklankrol ESD 60
  • Perlandrol L
  • Product No. 161
  • Product No. 75
  • Richonol C
  • Richonol AF
  • Sipex SD
  • Sipex SP
  • Sodium lauryl sulfate 30%
  • Sodium lauryl sulfate, dental grade
  • Sodium lauryl sulfate ether
  • Sodium monododecyl sulfate
  • Sodiumlauryl ether sulfate
  • Solsol needles
  • Standapol WA-AC
  • Standapol WAS 100
  • Stepanol ME Dry
  • Stepanol methyl
  • Stepanol methyl dry AW
  • Stepanol WA-100
  • Stepanol WAQ
  • Sterling WA paste
  • Natrium laurylsulfuricum
  • Natriumlaurylsulfat
  • Laurylsiran sodny
  • UNII-368GB5141J
  • SLS
  • 1000201-72-8
  • 1000201-73-9
  • 111726-87-5
  • 121481-64-9
  • 12738-53-3
  • 12765-21-8
  • 129203-37-8
  • 1334-67-4
  • 1335-72-4
  • 145269-44-9
  • 152155-52-7
  • 156108-01-9
  • 172826-72-1
  • 191490-40-1
  • 210297-21-5
  • 237743-45-2
  • 303179-49-9
  • 39384-36-6
  • 51222-39-0
  • 57176-54-2
  • 58640-35-0
  • 61711-39-5
  • 64441-33-4
  • 74433-77-5
  • 8012-56-4
  • 8048-56-4
  • 877454-24-5
  • 952055-37-7
  • 952092-90-9

Applications:

HPLC Method for Separation of Hydrotopic, Cationic and Anion Surfactants on Newcrom BH Column

July 10, 2023

HPLC Method for Analysis of Hydrotopic, Cationic and Anion Surfactants on Newcrom BH by SIELC Technologies

Separation type: Liquid Chromatography Mixed-mode

HPLC Method for Separation of Hydrotopic, Cationic and Anion Surfactants

Surfactants, also known as surface-active agents, are compounds that lower the surface tension (or interfacial tension) between two liquids or between a liquid and a solid. Surfactants may act as detergents, wetting agents, emulsifiers, foaming agents, or dispersants.

They are often classified according to the charge of the polar head group:

Anionic Surfactants: These surfactants have a negative charge on their polar head group. Common examples include soap, sodium laureth sulfate, and sodium lauryl sulfate. They are commonly used in detergents and shampoos due to their ability to emulsify oils and hold dirt in suspension, so it can be rinsed away.

Cationic Surfactants: These surfactants have a positive charge on their polar head group. Examples include cetyltrimethylammonium bromide (CTAB) and benzalkonium chloride. These are often used as antiseptics and can also be found in hair conditioners because they reduce static cling.

Nonionic Surfactants: These surfactants have no charge on their polar head group. Examples include alcohol ethoxylates, nonylphenol ethoxylates, and polysorbates. Nonionic surfactants are often used in laundry and dishwasher detergents.

Hydrotropic Surfactants: While not a category of charge like the others, hydrotropic surfactants are a distinct class that promote the solubility of other solutes in water. Sodium xylene sulfonate and sodium cumene sulfonate are examples of hydrotropes.

The selection of a specific type of surfactant depends on the specific application and the properties of the surfactant. Some surfactants can be aggressive and irritating to skin or eyes (like certain anionic surfactants), while others are milder. Similarly, some are better at emulsifying oil or suspending dirt, while others might provide good foaming action or work better in hard water.

All compounds can be retained, separated, and analyzed using a reverse-phase Newcrom BH, 4.6 x 150 mm, 5 µm, 100 A column. The mobile phase for this method consists of water, acetonitrile (MeCN), and Ammonium formate, which serves as a buffer. This analytical method can be detected with an Evaporative Light Scattering Detector (ELSD) or any other evaporative detection method (CAD, ESI-MS).

High Performance Liquid Chromatography (HPLC) Method for Analysis of Benzalkonium chloride, Cetylpyridinium Chloride, 1-Pentanesulfonic acid, Dodecanoic acid (Lauric acid), p-Toluenesulfonic Acid (PTSA), 1-Octanesulfonic acid, Sodium dodecyl sulfate, 1-Ethylpyridinium bromide

Condition

ColumnNewcrom BH, 4.6 x 150 mm, 5 µm, 100 A
Mobile PhaseGradient MeCN -40-80%, 10 min
BufferAmmonium formate pH 3.0 – 40 mM
Flow Rate1.0 ml/min
DetectionELSD, 50C

Description

Class of CompoundsSurfactants
Analyzing CompoundsBenzalkonium chloride, Cetylpyridinium Chloride, 1-Pentanesulfonic acid, Dodecanoic acid (Lauric acid), p-Toluenesulfonic Acid (PTSA), 1-Octanesulfonic acid, Sodium dodecyl sulfate, 1-Ethylpyridinium bromide

Application Column

Newcrom BH

Column Diameter: 4.6 mm
Column Length: 150 mm
Particle Size: 5 µm
Pore Size: 100 A

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Application Analytes:
1-Ethylpyridinium bromide
1-Octanesulfonic acid
1-Pentanesulfonic acid
Benzalkonium chloride
Cetylpyridinium Chloride
Dodecanoic acid (Lauric acid)
Sodium dodecyl sulfate
p-Toluenesulfonic Acid (PTSA)

Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

HPLC Method for Separation of Hydrotopic, Cationic, Nonionic and Anion Surfactants on Newcrom BH Column

July 10, 2023

HPLC Method for Analysis of Hydrotopic, Cationic, Nonionic and Anion Surfactants on Newcrom BH by SIELC Technologies

Separation type: Liquid Chromatography Mixed-mode

HPLC Method for Separation of Hydrotopic, Cationic, Nonionic and Anion Surfactants on Newcrom BH Column
HPLC Method for Separation of Hydrotopic, Cationic, Nonionic and Anion Surfactants

Surfactants, also known as surface-active agents, are compounds that lower the surface tension (or interfacial tension) between two liquids or between a liquid and a solid. Surfactants may act as detergents, wetting agents, emulsifiers, foaming agents, or dispersants.

They are often classified according to the charge of the polar head group:

Anionic Surfactants: These surfactants have a negative charge on their polar head group. Common examples include soap, sodium laureth sulfate, and sodium lauryl sulfate. They are commonly used in detergents and shampoos due to their ability to emulsify oils and hold dirt in suspension, so it can be rinsed away.

Cationic Surfactants: These surfactants have a positive charge on their polar head group. Examples include cetyltrimethylammonium bromide (CTAB) and benzalkonium chloride. These are often used as antiseptics and can also be found in hair conditioners because they reduce static cling.

Nonionic Surfactants: These surfactants have no charge on their polar head group. Examples include alcohol ethoxylates, nonylphenol ethoxylates, and polysorbates. Nonionic surfactants are often used in laundry and dishwasher detergents.

Hydrotropic Surfactants: While not a category of charge like the others, hydrotropic surfactants are a distinct class that promote the solubility of other solutes in water. Sodium xylene sulfonate and sodium cumene sulfonate are examples of hydrotropes.

The selection of a specific type of surfactant depends on the specific application and the properties of the surfactant. Some surfactants can be aggressive and irritating to skin or eyes (like certain anionic surfactants), while others are milder. Similarly, some are better at emulsifying oil or suspending dirt, while others might provide good foaming action or work better in hard water.

All compounds can be retained, separated, and analyzed using a reverse-phase Newcrom BH, 4.6 x 250 mm, 5 µm, 100 A column. The mobile phase for this method consists of water, acetonitrile (MeCN), and Ammonium formate, which serves as a buffer. This analytical method can be detected with an Evaporative Light Scattering Detector (ELSD) or any other evaporative detection method (CAD, ESI-MS).

High Performance Liquid Chromatography (HPLC) Method for Analysis of Benzalkonium chloride, Cetylpyridinium Chloride, Triton X100, 1-Pentanesulfonic acid, 1-Hexanesulfonic acid, sodium salt, 1-Heptanesulfonic acid, 1-Decanesulfonic acid, Sodium dodecyl sulfate, 1-Octanesulfonic acid

Condition

ColumnNewcrom BH, 4.6 x 250 mm, 5 µm, 100 A
Mobile PhaseGradient MeCN -40-80%, 30 min
BufferAmmonium formate pH 3.0 – 20 mM
Flow Rate1.0 ml/min
DetectionELSD, 50C

Description

Class of CompoundsAliphatic sulfonic acid
Analyzing CompoundsBenzalkonium chloride, Cetylpyridinium Chloride, Triton X100, 1-Pentanesulfonic acid, 1-Hexanesulfonic acid, sodium salt, 1-Heptanesulfonic acid, 1-Decanesulfonic acid, Sodium dodecyl sulfate, 1-Octanesulfonic acid

Application Column

Newcrom BH

Column Diameter: 4.6 mm
Column Length: 250 mm
Particle Size: 5 µm
Pore Size: 100 A

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Application Analytes:
1-Decanesulfonic acid
1-Heptanesulfonic acid
1-Hexanesulfonic acid, sodium salt
1-Octanesulfonic acid
1-Pentanesulfonic acid
Benzalkonium chloride
Cetylpyridinium Chloride
Sodium dodecyl sulfate
Triton X100
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

HPLC Determination of Sodium Dodecyl Sulfate on Newcrom BH and Newcrom B Columns

April 7, 2020


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Sodium dodecyl sulfate, or sodium lauryl sulfate, is a surfactant used in cleaning and hygienic products. It has a twelve carbon hydrophobic tail attached to a polar sulfate. Dodecyl sulfate can be retained on Newcrom B and BH  columns in under 10 minutes with an MS-compatible mobile phase.

Condition

Column Newcrom BH, Newcrom B  4.6×150 mm, 5 µm, 100A
Mobile Phase MeCN/H2O – 70/30%
Buffer AmFm pH 3.0 – 60 mM
Flow Rate 1.0 ml/min
Detection CAD (Corona) MS- compatible mobile phase

 

Description

Class of Compounds
Hydrophobic, Base, Ionizable, Anionic surfactant
Analyzing Compounds Sodium Dodecyl Sulfate

 

Application Column

Newcrom B

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Newcrom BH

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

Select options
Application Analytes:
Sodium dodecyl sulfate
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

HPLC Determination of Sodium Dodecyl Sulfate on Primesep B4 Column

June 7, 2019

HPLC Determination of Sodum Dodecyl Sulfate

Sodium dodecyl sulfate, or sodium lauryl sulfate, is a surfactant used in cleaning and hygienic products. It has a twelve carbon hydrophobic tail attached to a polar sulfate. Dodecyl sulfate can be retained on Primesep B4 column in under 5 minutes with an MS-compatible mobile phase. Primesep B4 is a short carbon chain reverse-phase (RP) mixed-mode column with embedded basic ion-pairing groups.

 

Condition

Column Primesep B4, 4.6×150 mm, 5 µm, 100A
Mobile Phase MeCN/H2O – 60/40%
Buffer AmFm pH 3.0 – 30 mM
Flow Rate 1.0 ml/min
Detection CAD (Corona) MS- compatible mobile phase

 

Description

Class of Compounds
Hydrophobic, Base, Ionizable, Anionic surfactant
Analyzing Compounds Sodium Dodecyl Sulfate

 

Application Column

Primesep B4

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

Select options
Application Analytes:
Sodium dodecyl sulfate
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

Separation of Sodium dodecyl sulfate on Newcrom R1 HPLC column

February 16, 2018

Sodium dodecyl sulfate can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

Select options
Application Analytes:
Sodium dodecyl sulfate
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.