Sulfadiazine

CAS Number 68-35-9
Molecular Formula C10H10N4O2S
Molecular Weight 260.28 g/mol
InChI Key SEEPANYCNGTZFQ-UHFFFAOYSA-N
LogP -0.1
Synonyms
  • sulfadiazine
  • 68-35-9
  • Sulphadiazine
  • Sulfapyrimidine
  • Sulfadiazin
  • Sulfazine
  • Sulfadiazene
  • Adiazine
  • Adiazin
  • Debenal
  • Liquadiazine
  • Sulfapyrimidin
  • Pyrimal
  • 2-Sulfanilamidopyrimidine
  • Cremodiazine
  • Spofadrizine
  • Theradiazine
  • Cremotres
  • Deltazina
  • Diazolone
  • Eskadiazine
  • Microsulfon
  • Neotrizine
  • Palatrize
  • Piridisir
  • Quadetts
  • Quadramoid
  • Sanodiazine
  • Sterazine
  • Sulfatryl
  • Sulfolex
  • Sulfonsol
  • Terfonyl
  • Trifonamide
  • Truozine
  • Diazin
  • Diazyl
  • Neazine
  • Pirimal
  • Sulfose
  • Trisem
  • Sulfanilamidopyrimidine
  • Honey diazine
  • Lipo-Levazine
  • Tri-Sulfameth
  • Triple Sulfas
  • Coco-Diazine
  • Lipo-Diazine
  • Metha-Meridiazine
  • Sulfadiazinum
  • Diazovit
  • Sulfadiazina
  • Sulphadiazine E
  • Sulfapirimidin
  • Di-Azo-Mul
  • Thi-Di-Mer
  • 2-Sulfanilylaminopyrimidine
  • Codiazine
  • Silvadene
  • Pecta-diazine, suspension
  • Benzenesulfonamide, 4-amino-N-2-pyrimidinyl-
  • CocoDiazine
  • Solfadiazina [DCIT]
  • RP 2616
  • 4-amino-N-(pyrimidin-2-yl)benzenesulfonamide
  • Pyrimidine, 2-sulfanilamido-
  • 2-Sulfanilamidopyrimidin
  • Sulfapyrimidin [German]
  • 2-Sulfapyrimidine
  • Sulfonamides Duplex
  • Sulfadiazinum [INN-Latin]
  • Sulfadiazina [INN-Spanish]
  • 4-AMINO-N-2-PYRIMIDINYLBENZENESULFONAMIDE
  • Zinc Sulfadiazine
  • N(1)-2-pyrimidylsulfanilamide
  • N(1)-2-pyrimidinylsulfanilamide
  • 2-Sulfanilamidopyrimidin [German]
  • S.N. 112
  • 4-amino-N-pyrimidin-2-ylbenzenesulfonamide
  • A 306
  • A-306 (VAN)
  • N(sup 1)-2-Pyrimidinylsulfanilamide
  • MFCD00006065
  • Thermazene
  • N1-2-Pyrimidinylsulfanilamide
  • Sildaflo
  • CHEBI:9328
  • Sulfanilamide, N(sup 1)-2-pyrimidinyl-
  • N(sup1)-2-Pyrimidylsulfanilamide
  • Sulfanilamide, N1-2(1H)-pyrimidinylidene-
  • 4-Amino-N-(2-pyrimidinyl)benzenesulfonamide
  • 4-amino-N-pyrimidin-2-yl-benzenesulfonamide
  • N1-(Pyrimidin-2-yl)sulfanilamide
  • Sulfanilamide, N1-2-pyrimidinyl-
  • UNII-0N7609K889
  • A-306
  • N(sup1)-2-Pyrimidinylsulfanilamide
  • EINECS 200-685-8
  • NSC 35600
  • 4-amino-N-(pyrimidin-2-yl)benzene-1-sulfonamide
  • CHEMBL439
  • N1-2-Pyrimidylsulfanilamide
  • BRN 0235192
  • C10H10N4O2S
  • Triple sulfa
  • 4-Amino-N-2-pyrimidinyl-benzenesulfonamide
  • AI3-01047
  • S. N. 112
  • SEEPANYCNGTZFQ-UHFFFAOYSA-N
  • N(1)-(2-Pyrimidinyl)sulfanilamide
  • NSC35600
  • CAS-68-35-9
  • NCGC00016305-01
  • Solfadiazina
  • 0N7609K889
  • [(4-aminophenyl)sulfonyl]pyrimidin-2-ylamine
  • NSC117870
  • Pecta-Diazine
  • SMR000059113
  • Sulfadiazine (TN)
  • N-(2-Pyrimidinyl)sulfanilamide
  • Sulfadiazine [USAN:INN:JAN]
  • rBPI21 & Sulfa
  • SR-01000002973
  • SSD
  • 2-Sulfanilamido-pyrimidine
  • CRL-8131 & Sulfadiazine
  • Sulfadiazine (JAN/USP/INN)
  • Sulfadiazine,(S)
  • Trisulfapyrimidine, oral suspension
  • Sulfadiazine [USP:INN:BAN:JAN]
  • DRG-0214
  • Prestwick_428
  • Spectrum_000986
  • Sulfadiazina Reig Jofre
  • Sulfacombin (Salt/Mix)
  • AC1L1JUR
  • Prestwick0_000023
  • Prestwick1_000023
  • Prestwick2_000023
  • Prestwick3_000023
  • Spectrum2_001319
  • Spectrum3_001362
  • Spectrum4_000342
  • Spectrum5_000992
  • Epitope ID:140083
  • AC1Q51XM
  • AC1Q6W1E
  • Sulfadiazine, >=99.0%
  • DSSTox_CID_24130
  • DSSTox_RID_80105
  • DSSTox_GSID_44130
  • Oprea1_081078
  • SCHEMBL24176
  • BSPBio_000085
  • BSPBio_002884
  • KBioGR_000743
  • KBioSS_001466
  • 5-25-10-00067 (Beilstein Handbook Reference)
  • MLS000069423
  • MLS006011457
  • DivK1c_000543
  • SPECTRUM1500546
  • SPBio_001417
  • SPBio_002006
  • BPBio1_000095
  • WLN: T6N CNJ BMSWR DZ
  • DTXSID7044130
  • CTK7D7930
  • HMS501L05
  • KBio1_000543
  • KBio2_001466
  • KBio2_004034
  • KBio2_006602
  • KBio3_002104
  • NINDS_000543
  • HMS1568E07
  • HMS1921A13
  • HMS2090P09
  • HMS2092I15
  • HMS2095E07
  • HMS2235D19
  • HMS3371L19
  • HMS3655I10
  • HMS3712E07
  • Pharmakon1600-01500546
  • ZINC120319
  • ALBB-014888
  • BCP12140
  • HY-B0273
  • Tox21_110360
  • BBL013169
  • BDBM50166571
  • CCG-39257
  • NSC-35600
  • NSC757324
  • Recombinant bactericidal/permeability-increasing protein & Sulfadiazine
  • s1770
  • SBB007604
  • SBB057674
  • STK317797
  • 2-(p-Aminobenzenesulfonamido)pyrimidin
  • AKOS000119073
  • CS-2263
  • DB00359
  • KS-1144
  • MCULE-4577338719
  • NE10425
  • NSC-757324
  • RP17586
  • 2-(4-Aminobenzenesulfonamido)pyrimidine
  • 4-amino-N-2-pyrimidylbenzenesulfonamide
  • IDI1_000543
  • N1-2(1H)-pyrimidinylidene-sulfanilamide
  • NCGC00016305-02
  • NCGC00016305-03
  • NCGC00016305-04
  • NCGC00016305-05
  • NCGC00016305-06
  • NCGC00016305-10
  • NCGC00023291-03
  • NCGC00023291-04
  • SULFADIAZINE (TRISULFAPYRIMIDINES)
  • 2-(4-Aminobenzenesulfonylamino)pyrimidine
  • AC-26817
  • AK321973
  • H458
  • ST059447
  • Sulfanilamide, N1-2-pyrimidinyl- (8CI)
  • ZB004097
  • Mixture of sulfadiazine, and sulfamethazine
  • SBI-0051520.P003
  • AB2000282
  • LS-147838
  • 4-[[(Pyrimidin-2-yl)amino]sulfonyl]aniline
  • 4-Amino-N-2-pyrimidinyl- benzenesulfonamide
  • AB00052095
  • Benzenesulfonamide,4-amino-N-2-pyrimidinyl-
  • FT-0674741
  • R3929
  • S0579
  • ST51006797
  • SW196657-3
  • TL80073596
  • 4-amino-N-(2-pyrimidinyl) benzenesulfonamide
  • 4-Amino-n-(2-pyrimidinyl)benzene-sulfonamide
  • 4-Amino-N-(2-pyrimidinyl)benzenesulfonamide
  • #68S359
  • C07658
  • D00587
  • Trisulfapyrimidine, oral suspension (Salt/Mix)
  • AB00052095-13
  • AB00052095-14
  • AB00052095_15
  • AB00052095_16
  • Benzenesulfonamide, 4-amino-N-(2-pyrimidinyl)-
  • Sulfadiazine, VETRANAL(TM), analytical standard
  • Q-201759
  • SR-01000002973-2
  • SR-01000002973-3
  • BRD-K32273377-001-05-4
  • BRD-K32273377-001-09-6
  • I01-15838
  • F1657-1720
  • I14-110269
  • Sulfadiazine, certified reference material, TraceCERT(R)
  • Z271004844
  • Sulfadiazine, European Pharmacopoeia (EP) Reference Standard
  • Sulfadiazine, United States Pharmacopeia (USP) Reference Standard
  • 4-Amino-N-(2-pyrimidinyl)benzenesulfonamide, N1-(Pyrimidin-2-yl)sulfanilamide
  • Sulfadiazine, Pharmaceutical Secondary Standard; Certified Reference Material
  • 141582-64-1

Applications:


HPLC Method for Analysis of Sulfadiazine, Naphthylthiourea, Sulfamethazine, Dexamethasone, Cortisone 21-Acetate
Sulfadiazine is an antibiotic used to prevent rheumatic fever, chancroid, chlamydia and infections by Haemophilus influenzae. There are side effects to the use of the drug which include, but not limited to: nausea, headache, rash, depression.  

Condition

Column Primesep 100, 3.2x50 mm, 5 µm, 100A
Mobile Phase Gradient MeCN - 20-75%, 4 min
Buffer Gradient H3PO4 - 0.05-0.2%, 4 min
Flow Rate 0.5 ml/min
Detection UV, 270 nm
 

Description

Class of Compounds Drug, Acid, Hydrophilic, Ionizable
Analyzing Compounds Sulfadiazine, Naphthylthiourea, Sulfamethazine, Dexamethasone, Cortisone 21-Acetate
 

Application Analytes:

Cortisone 21-Acetate
Dexamethasone
Naphthylthiourea
Sulfadiazine
Sulfamethazine

HPLC Separation of Antibiotics
HPLC.cloud View on hplc.cloud Antibiotics are widely used for treatment and prevention of bacterial infections.  Various antibiotics, particularly those with a sulfanilamide structure, were separated in HPLC using mixed-mode columns with varying strengths of ion-pairing groups.  Primesep 200 has weak acidic ion-exchange pairing groups while Newcrom A has strong acidic ion-exchange groups.  In addition, methanol can be used in the mobile phase on Newcrom A column.  The antibiotics were resolved on both columns with a gradient mobile phase consisting of acetonitrile (ACN) or methanol (MeOH), water and sulfuric acid (H2SO4) buffer.  UV detection at 275nm.

Condition 1

Column Primesep 200, 4.6x100 mm, 5 µm, 100A
Mobile Phase MeCN Gradient
Buffer H2SO4 - 0.5%
Flow Rate 1.0 ml/min
Detection UV 275 nm

Condition 2

Column Newcrom A, 3.2x100 mm, 5 µm, 100A
Mobile Phase MeOH Gradient
Buffer H2SO4 Gradient
Flow Rate  0.5 ml/min
Detection UV 275 nm
 

Description

Class of Compounds Drugs, Antibiotics
Analyzing Compounds Sulfanilamide, Sulfadiazine, Sulfaguanidine, Dapsone, Sulfaquinoxaline


Application Analytes:

Dapsone
Sulfadiazine
Sulfaguanidine
Sulfanilamide
Sulphaquinoxaline