Sulfadiazine

CAS Number68-35-9
Molecular FormulaC10H10N4O2S
Molecular Weight260.28
InChI KeySEEPANYCNGTZFQ-UHFFFAOYSA-N
LogP-0.1
Synonyms
  • sulfadiazine
  • 68-35-9
  • Sulphadiazine
  • Sulfapyrimidine
  • Sulfadiazin
  • Sulfazine
  • Sulfadiazene
  • Adiazine
  • Adiazin
  • Debenal
  • Liquadiazine
  • Sulfapyrimidin
  • Pyrimal
  • 2-Sulfanilamidopyrimidine
  • Cremodiazine
  • Spofadrizine
  • Theradiazine
  • Cremotres
  • Deltazina
  • Diazolone
  • Eskadiazine
  • Microsulfon
  • Neotrizine
  • Palatrize
  • Piridisir
  • Quadetts
  • Quadramoid
  • Sanodiazine
  • Sterazine
  • Sulfatryl
  • Sulfolex
  • Sulfonsol
  • Terfonyl
  • Trifonamide
  • Truozine
  • Diazin
  • Diazyl
  • Neazine
  • Pirimal
  • Sulfose
  • Trisem
  • Sulfanilamidopyrimidine
  • Honey diazine
  • Lipo-Levazine
  • Tri-Sulfameth
  • Triple Sulfas
  • Coco-Diazine
  • Lipo-Diazine
  • Metha-Meridiazine
  • Sulfadiazinum
  • Diazovit
  • Sulfadiazina
  • Sulphadiazine E
  • Sulfapirimidin
  • Di-Azo-Mul
  • Thi-Di-Mer
  • 2-Sulfanilylaminopyrimidine
  • Codiazine
  • Silvadene
  • Pecta-diazine, suspension
  • Benzenesulfonamide, 4-amino-N-2-pyrimidinyl-
  • CocoDiazine
  • Solfadiazina [DCIT]
  • RP 2616
  • 4-amino-N-(pyrimidin-2-yl)benzenesulfonamide
  • Pyrimidine, 2-sulfanilamido-
  • 2-Sulfanilamidopyrimidin
  • Sulfapyrimidin [German]
  • 2-Sulfapyrimidine
  • Sulfonamides Duplex
  • Sulfadiazinum [INN-Latin]
  • Sulfadiazina [INN-Spanish]
  • 4-AMINO-N-2-PYRIMIDINYLBENZENESULFONAMIDE
  • Zinc Sulfadiazine
  • N(1)-2-pyrimidylsulfanilamide
  • N(1)-2-pyrimidinylsulfanilamide
  • 2-Sulfanilamidopyrimidin [German]
  • S.N. 112
  • 4-amino-N-pyrimidin-2-ylbenzenesulfonamide
  • A 306
  • A-306 (VAN)
  • N(sup 1)-2-Pyrimidinylsulfanilamide
  • MFCD00006065
  • Thermazene
  • N1-2-Pyrimidinylsulfanilamide
  • Sildaflo
  • CHEBI:9328
  • Sulfanilamide, N(sup 1)-2-pyrimidinyl-
  • N(sup1)-2-Pyrimidylsulfanilamide
  • Sulfanilamide, N1-2(1H)-pyrimidinylidene-
  • 4-Amino-N-(2-pyrimidinyl)benzenesulfonamide
  • 4-amino-N-pyrimidin-2-yl-benzenesulfonamide
  • N1-(Pyrimidin-2-yl)sulfanilamide
  • Sulfanilamide, N1-2-pyrimidinyl-
  • UNII-0N7609K889
  • A-306
  • N(sup1)-2-Pyrimidinylsulfanilamide
  • EINECS 200-685-8
  • NSC 35600
  • 4-amino-N-(pyrimidin-2-yl)benzene-1-sulfonamide
  • CHEMBL439
  • N1-2-Pyrimidylsulfanilamide
  • BRN 0235192
  • C10H10N4O2S
  • Triple sulfa
  • 4-Amino-N-2-pyrimidinyl-benzenesulfonamide
  • AI3-01047
  • S. N. 112
  • SEEPANYCNGTZFQ-UHFFFAOYSA-N
  • N(1)-(2-Pyrimidinyl)sulfanilamide
  • NSC35600
  • CAS-68-35-9
  • NCGC00016305-01
  • Solfadiazina
  • 0N7609K889
  • [(4-aminophenyl)sulfonyl]pyrimidin-2-ylamine
  • NSC117870
  • Pecta-Diazine
  • SMR000059113
  • Sulfadiazine (TN)
  • N-(2-Pyrimidinyl)sulfanilamide
  • Sulfadiazine [USAN:INN:JAN]
  • rBPI21 & Sulfa
  • SR-01000002973
  • SSD
  • 2-Sulfanilamido-pyrimidine
  • CRL-8131 & Sulfadiazine
  • Sulfadiazine (JAN/USP/INN)
  • Sulfadiazine,(S)
  • Trisulfapyrimidine, oral suspension
  • Sulfadiazine [USP:INN:BAN:JAN]
  • DRG-0214
  • Prestwick_428
  • Spectrum_000986
  • Sulfadiazina Reig Jofre
  • Sulfacombin (Salt/Mix)
  • AC1L1JUR
  • Prestwick0_000023
  • Prestwick1_000023
  • Prestwick2_000023
  • Prestwick3_000023
  • Spectrum2_001319
  • Spectrum3_001362
  • Spectrum4_000342
  • Spectrum5_000992
  • Epitope ID:140083
  • AC1Q51XM
  • AC1Q6W1E
  • Sulfadiazine, >=99.0%
  • DSSTox_CID_24130
  • DSSTox_RID_80105
  • DSSTox_GSID_44130
  • Oprea1_081078
  • SCHEMBL24176
  • BSPBio_000085
  • BSPBio_002884
  • KBioGR_000743
  • KBioSS_001466
  • 5-25-10-00067 (Beilstein Handbook Reference)
  • MLS000069423
  • MLS006011457
  • DivK1c_000543
  • SPECTRUM1500546
  • SPBio_001417
  • SPBio_002006
  • BPBio1_000095
  • WLN: T6N CNJ BMSWR DZ
  • DTXSID7044130
  • CTK7D7930
  • HMS501L05
  • KBio1_000543
  • KBio2_001466
  • KBio2_004034
  • KBio2_006602
  • KBio3_002104
  • NINDS_000543
  • HMS1568E07
  • HMS1921A13
  • HMS2090P09
  • HMS2092I15
  • HMS2095E07
  • HMS2235D19
  • HMS3371L19
  • HMS3655I10
  • HMS3712E07
  • Pharmakon1600-01500546
  • ZINC120319
  • ALBB-014888
  • BCP12140
  • HY-B0273
  • Tox21_110360
  • BBL013169
  • BDBM50166571
  • CCG-39257
  • NSC-35600
  • NSC757324
  • Recombinant bactericidal/permeability-increasing protein & Sulfadiazine
  • s1770
  • SBB007604
  • SBB057674
  • STK317797
  • 2-(p-Aminobenzenesulfonamido)pyrimidin
  • AKOS000119073
  • CS-2263
  • DB00359
  • KS-1144
  • MCULE-4577338719
  • NE10425
  • NSC-757324
  • RP17586
  • 2-(4-Aminobenzenesulfonamido)pyrimidine
  • 4-amino-N-2-pyrimidylbenzenesulfonamide
  • IDI1_000543
  • N1-2(1H)-pyrimidinylidene-sulfanilamide
  • NCGC00016305-02
  • NCGC00016305-03
  • NCGC00016305-04
  • NCGC00016305-05
  • NCGC00016305-06
  • NCGC00016305-10
  • NCGC00023291-03
  • NCGC00023291-04
  • SULFADIAZINE (TRISULFAPYRIMIDINES)
  • 2-(4-Aminobenzenesulfonylamino)pyrimidine
  • AC-26817
  • AK321973
  • H458
  • ST059447
  • Sulfanilamide, N1-2-pyrimidinyl- (8CI)
  • ZB004097
  • Mixture of sulfadiazine, and sulfamethazine
  • SBI-0051520.P003
  • AB2000282
  • LS-147838
  • 4-[[(Pyrimidin-2-yl)amino]sulfonyl]aniline
  • 4-Amino-N-2-pyrimidinyl- benzenesulfonamide
  • AB00052095
  • Benzenesulfonamide,4-amino-N-2-pyrimidinyl-
  • FT-0674741
  • R3929
  • S0579
  • ST51006797
  • SW196657-3
  • TL80073596
  • 4-amino-N-(2-pyrimidinyl) benzenesulfonamide
  • 4-Amino-n-(2-pyrimidinyl)benzene-sulfonamide
  • 4-Amino-N-(2-pyrimidinyl)benzenesulfonamide
  • #68S359
  • C07658
  • D00587
  • Trisulfapyrimidine, oral suspension (Salt/Mix)
  • AB00052095-13
  • AB00052095-14
  • AB00052095_15
  • AB00052095_16
  • Benzenesulfonamide, 4-amino-N-(2-pyrimidinyl)-
  • Sulfadiazine, VETRANAL(TM), analytical standard
  • Q-201759
  • SR-01000002973-2
  • SR-01000002973-3
  • BRD-K32273377-001-05-4
  • BRD-K32273377-001-09-6
  • I01-15838
  • F1657-1720
  • I14-110269
  • Sulfadiazine, certified reference material, TraceCERT(R)
  • Z271004844
  • Sulfadiazine, European Pharmacopoeia (EP) Reference Standard
  • Sulfadiazine, United States Pharmacopeia (USP) Reference Standard
  • 4-Amino-N-(2-pyrimidinyl)benzenesulfonamide, N1-(Pyrimidin-2-yl)sulfanilamide
  • Sulfadiazine, Pharmaceutical Secondary Standard; Certified Reference Material
  • 141582-64-1

Applications:

HPLC Separation of Antibiotics

June 11, 2020


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Antibiotics are widely used for treatment and prevention of bacterial infections.  Various antibiotics, particularly those with a sulfanilamide structure, were separated in HPLC using mixed-mode columns with varying strengths of ion-pairing groups.  Primesep 200 has weak acidic ion-exchange pairing groups while Newcrom A has strong acidic ion-exchange groups.  In addition, methanol can be used in the mobile phase on Newcrom A column.  The antibiotics were resolved on both columns with a gradient mobile phase consisting of acetonitrile (ACN) or methanol (MeOH), water and sulfuric acid (H2SO4) buffer.  UV detection at 275nm.

Condition 1

Column Primesep 200, 4.6×100 mm, 5 µm, 100A
Mobile Phase MeCN Gradient
Buffer H2SO4 – 0.5%
Flow Rate 1.0 ml/min
Detection UV 275 nm

Condition 2

Column Newcrom A, 3.2×100 mm, 5 µm, 100A
Mobile Phase MeOH Gradient
Buffer H2SO4 Gradient
Flow Rate  0.5 ml/min
Detection UV 275 nm

 

Description

Class of Compounds Drugs, Antibiotics
Analyzing Compounds Sulfanilamide, Sulfadiazine, Sulfaguanidine, Dapsone, Sulfaquinoxaline

Application Column

Primesep 200

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

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Newcrom A

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

Select options
Application Analytes:
Dapsone
Sulfadiazine
Sulfaguanidine
Sulfanilamide
Sulphaquinoxaline
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

HPLC Method for Analysis of Sulfadiazine, Naphthylthiourea, Sulfamethazine, Dexamethasone, Cortisone 21-Acetate

July 11, 2017

Sulfadiazine is an antibiotic used to prevent rheumatic fever, chancroid, chlamydia and infections by Haemophilus influenzae. There are side effects to the use of the drug which include, but not limited to: nausea, headache, rash, depression.

 

Condition

Column Primesep 100, 3.2×50 mm, 5 µm, 100A
Mobile Phase Gradient MeCN – 20-75%, 4 min
Buffer Gradient H3PO4 – 0.05-0.2%, 4 min
Flow Rate 0.5 ml/min
Detection UV, 270 nm

 

Description

Class of Compounds
Drug, Acid, Hydrophilic, Ionizable
Analyzing Compounds Sulfadiazine, Naphthylthiourea, Sulfamethazine, Dexamethasone, Cortisone 21-Acetate

 

Application Column

Primesep 100

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

Select options
Application Analytes:
Cortisone 21-Acetate
Dexamethasone
Naphthylthiourea
Sulfadiazine
Sulfamethazine
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.