Sulfamethazine

CAS Number 57-68-1
Molecular Formula C12H14N4O2S
Molecular Weight 278.330 g/mol
InChI Key ASWVTGNCAZCNNR-UHFFFAOYSA-N
LogP 0.19
Synonyms
  • Sulfamethazine
  • 4-Amino-N-(4,6-dimethylpyrimidin-2-yl)benzene-1-sulfonamide
  • Benzenesulfonamide, 4-amino-N-(4,6-dimethyl-2-pyrimidinyl)-
  • 57-68-1
  • 5-25-10-00250
  • Benzenesulfonamide, 4-amino-N-(4,6-dimethyl-2-pyrimidinyl)-
  • 2-(4-Aminobenzenesulfonamido)-4,6-dimethylpyrimidine
  • 2-(4-Aminobenzenesulfonylamino)-4,6-dimethylpyrimidine
  • 2-(p-Aminobenzenesulfonamido)-4,6-dimethylpyrimidine
  • 2-Sulfanilamido-4,6-dimethylpyrimidine
  • 4,6-Dimethyl-2-sulfanilamidopyrimidine
  • 4-Amino-N-(2,6-dimethyl-4-pyrimidinyl)benzenesulfonamide
  • 4-Amino-N-(4,6-dimethyl-2-pyrimidinyl)benzenesulfonamide
  • Azolmetazin
  • Calfspan
  • Calfspan Tablets
  • Cremomethazine
  • DiazilSulfadine
  • Dimezathine
  • Dimidin R
  • Kelametazine
  • Mermeth
  • N-(4,6-Dimethyl-2-pyrimidyl)sulfanilamide
  • N1-(4,6-Dimethyl-2-pyrimidinyl)sulfanilamide
  • N1-(4,6-Dimethyl-2-pyrimidyl)sulfanilamide
  • Neasina
  • Neazina
  • NSC 67457
  • NSC 683529
  • Panazin
  • Pirmazin
  • S-Dimidine
  • Spanbolet
  • Sulfadimerazine
  • Sulfadimesin
  • Sulfadimesine
  • Sulfadimethyldiazine
  • Sulfadimethylpyrimidine
  • Sulfadimezin
  • Sulfadimezine
  • Sulfadimidin
  • sulfadimidina
  • Sulfadimidine
  • Sulfadine
  • SULFAMETHAZINE BASE
  • Sulfamethiazine
  • Sulfanilamide, N1-(4,6-dimethyl-2-pyrimidinyl)-
  • SulfaSURE SR Bolus
  • Sulfodimesin
  • Sulfodimezine
  • Sulka K Boluses
  • Sulphadimethylpyrimidine
  • Sulphadimidine
  • Sulphamethasine
  • Sulphamethazine
  • Sulphamezathine
  • Sulphamidine
  • Sulphodimezine
  • Superseptil
  • Superseptyl
  • Sustain III
  • Vertolan
  • Benzenesulfonamide, 4-amino-N-(2,6-dimethyl-4-pyrimidinyl)-
  • BRN 0261304
  • Dimidin-R
  • EINECS 200-346-4
  • Hava-Span
  • Intradine
  • NCI-C56600
  • Sulfadimezinum
  • Sulfa-Isodimerazine
  • Sulfanilamide, N(1)-(4,6-dimethyl-2-pyrimidinyl)-
  • Sulfanilamide, N(sup1)-(2,6-dimethyl-4-pyrimidinyl)-
  • Sulfanilamide, N(sup1)-(4,6-dimethyl-2-pyrimidinyl)-
  • N(sup 1)-(4,6-Dimethyl-2-pyrimidinyl)sulfanilamide
  • N(sup 1)-(4,6-Dimethyl-2-pyrimidyl)sulfanilamide
  • (p-Aminobenzolsulfonyl)-2-amino-4,6-dimethylpyrimidin
  • Solfadimidina
  • Sulfadimidinum
  • UNII-48U51W007F
  • Sentry aq mardel biospheres maracyn plus
  • 2-Sulfanilamido-4,6-dimethylpyrimidine
  • 4-Amino-N-(4,6-dimethyl-pyrimidin-2-yl)-benzenesulfonamide
  • 4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide
  • 6-(4'-Aminobenzol-sulfonamido)-2,4-dimethylpyrimidin
  • N(1)-(4,6-Dimethyl-2-pyrimidinyl)sulfanilamide
  • N(1)-(4,6-Dimethyl-2-pyrimidyl)sulfanilamide
  • N-(4,6-Dimethyl-2-pyrimidyl)sulfanilamide
  • SMZ
  • Sulfametazina
  • Sulfametazyny
  • Sulfamezathine
  • sulfamethazone

Applications:


HPLC Method for Analysis of Sulfadiazine, Naphthylthiourea, Sulfamethazine, Dexamethasone, Cortisone 21-Acetate
Sulfadiazine is an antibiotic used to prevent rheumatic fever, chancroid, chlamydia and infections by Haemophilus influenzae. There are side effects to the use of the drug which include, but not limited to: nausea, headache, rash, depression.  

Condition

Column Primesep 100, 3.2x50 mm, 5 µm, 100A
Mobile Phase Gradient MeCN - 20-75%, 4 min
Buffer Gradient H3PO4 - 0.05-0.2%, 4 min
Flow Rate 0.5 ml/min
Detection UV, 270 nm
 

Description

Class of Compounds Drug, Acid, Hydrophilic, Ionizable
Analyzing Compounds Sulfadiazine, Naphthylthiourea, Sulfamethazine, Dexamethasone, Cortisone 21-Acetate
 

Application Analytes:

Cortisone 21-Acetate
Dexamethasone
Naphthylthiourea
Sulfadiazine
Sulfamethazine

Separation of Sulfamethazine on Newcrom R1 HPLC column

Sulfamethazine can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Separation of Sulfamethazine on Newcrom C18 HPLC column
Newcrom R1

This column is available in new type of hardware with only one connection end. Learn more about performance and advantage of this new hardware.



Application Analytes:

Sulfamethazine