Sulfosuccinic acid

CAS Number 5138-18-1
Molecular Formula C4H6O7S
Molecular Weight 198.150 g/mol
LogP -1.66
  • Sulfosuccinic acid
  • 2-Sulfobutanedioato(2-)
  • Butanedioic acid, 2-sulfo-
  • 5138-18-1
  • Butanedioic acid, sulfo-
  • 2-Sulfosuccinic acid
  • Acide sulfosuccinique
  • acido sulfosuccinico
  • Butanedioic acid, 2-sulfo-
  • Succinic acid, sulfo-
  • Sulfobernsteinsaure
  • sulphosuccinic acid
  • Tegokat S 70
  • EINECS 225-898-3
  • 181719-29-9
  • 55904-24-0


HPLC Separation of Sodium, Dioctyl Sulfosuccinic Acid, and Sulfosuccinic Acid

Application Notes: Dioctyl sodium sulfosuccinate is a common component of consumer products and medications. It is also used as emulsifier, wetting, and dispersing agent.  It is a highly acidic, and hydrophobic compound. It serves as a starting material for dioctyl sodium sulfonate. Both compounds were retained and separated on Primesep B4 mixed-mode reversed-phase anion-exchange column. The primesep B4 column has C4 carbon chain and it is much less hydrophobic than Primesep D or Primesep B2 column. The low hydrophobicity of the stationary phase is strong enough to provide reversed-phase retention for dioctyl sulfosuccinic acid. This method can be used for quantification of these two compounds in reaction mixtures and formulation. The method is LC/MS and ELSD/CAD compatible.

Application Columns: Primesep B4

Application compounds: Sodium, Dioctyl Sulfosuccinic Acid, Sulfosuccinic Acid

Detection technique: LC/MS, ELSD/CAD

Application Analytes:

Sulfosuccinic acid

HPLC Analysis of Sulfosuccinic Acid on a Primesep S Column



Application Notes: Sulfosuccinic acid was retained on Primesep S HILIC/anion exclusion Primesep S column. Retention time is controlled by the amount of ACN, buffer pH and buffer concentration. Since the compound has no UV activity ELSD was used for monitoring and quantitation.
Application Columns: Primesep S
Application compounds: Sulfosuccinic Acid
Detection technique: UV, LC/MS, ELSD/CAD

Application Analytes:

Sulfosuccinic acid

The Separation of Sodium, Dioctylsulfosuccinic Acid, and Sulfosuccinic Acid

Sulfosuccininc acid and the corresponding dioctyl ester were separated on the Primesep B4 short carbon-chain anion-exchange column. Short carbon chain stationary phase allows to elute hydrophobic and acidic diester in reasonable time. No elution was observed on the mixed-mode columns with longer carbon chain analogs due to very strong hydrophobic and anion-exchange interaction.

Application Analytes:

Dioctyl sulfosuccinic acid
Sulfosuccinic acid