Tryptamine

CAS Number 61-54-1
Molecular Formula C10H12N2
Molecular Weight 160.221 g/mol
InChI Key APJYDQYYACXCRM-UHFFFAOYSA-N
LogP 1.55
Synonyms
  • Tryptamine
  • 2-(1H-Indol-3-yl)ethan-1-amine
  • 1H-Indole-3-ethanamine
  • 61-54-1
  • 5-22-10-00045
  • 1H-Indole-3-ethanamine
  • [2-(3-Indolyl)ethyl]amine
  • 2-(1H-Indol-3-yl)ethanamine
  • 2-(1H-Indol-3-yl)ethylamine
  • 2-(3-Indolyl)ethylamine
  • 2-(indol-3-il)etilamina
  • 2-(Indol-3-yl)ethylamin
  • 2-(indol-3-yl)ethylamine
  • 2-(indole-3-yl)ethylamine
  • 3-(2-Aminoethyl)-1H-indole
  • 3-(2-Aminoethyl)indole
  • 3-Indoleethanamine
  • 3-Indoleethylamine
  • Indole, 3-(2-aminoethyl)-
  • NSC 165212
  • Tryptamin
  • ?-(3-Indolyl)ethylamine
  • BRN 0125513
  • EINECS 200-510-5
  • Indol-3-ethylamine
  • (Amino-2 ethyl)-3 indole
  • UNII-422ZU9N5TV
  • (3-Indolyl)ethylamine
  • 2-(1H-indol-3-yl)ethan-1-amine
  • 2-Indol-3-yl-aethylamin
  • 2-Indol-3-yl-ethylamine

Applications:


Separation of Tryptamine on Newcrom R1 HPLC column

Tryptamine can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Separation of Tryptamine on Newcrom C18 HPLC column
Newcrom R1

This column is available in new type of hardware with only one connection end. Learn more about performance and advantage of this new hardware.



Application Analytes:

Tryptamine

HPLC Separation of Biogenic Amines on Primesep 100 Column
Tryptophan is an essential amino acid used in the synthesis of proteins. Tryptamine is structurally similar to tryptophan. Serotonin is a neurotransmitter derived from tryptophan. Dimethyltryptamine and 5-MeO-DMT are psychedelic substances derived from tryptamine. All the compounds have similar structures and can present difficulties to separation in reverse-phase HPLC. They can be separated using the Primesep 100 mixed-mode column in gradient analysis with acetonitrile (ACN) and water mobile phase with ammonium formate (AmFm) buffer, making the method MS-compatible. The amines can also be UV detected at 280nm.

Condition

Column Primesep 100, 4.6x150 mm, 5 µm, 100A
Mobile Phase Gradient MeCN - 40-50%, 15 min
Buffer Gradient AmFm pH 3.0- 20-80 mM, 15 min
Flow Rate 1.0 ml/min
Detection UV 280 nm,  MS-compatible mobile phase
 

Description

Class of Compounds Drug, Hydrophilic, Supplements, Monoamine,  Neurotransmitter
Analyzing Compounds Serotonin, Tryptophan, N,N-dimethyltryptophan, N,N-Dimethyl-5-methoxytryptamine, Tryptamine, N,N-dimethyltryptamine
 

Application Analytes:

N,N-Dimethyl-5-methoxytryptamine
N,N-Dimethyltryptamine
N,N-dimethyltryptophan
Serotonin
Tryptamine
Tryptophan